A comprehensive review of the current evidence for trabectedin in advanced myxoid liposarcoma.

Antineoplastic Agents, Alkylating / therapeutic use Humans Liposarcoma, Myxoid / drug therapy Trabectedin / therapeutic use
MLS Myxoid liposarcomas Trabectedin

Journal

Cancer treatment reviews
ISSN: 1532-1967
Titre abrégé: Cancer Treat Rev
Pays: Netherlands
ID NLM: 7502030

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 13 05 2018
revised: 12 11 2018
accepted: 14 11 2018
pubmed: 24 11 2018
medline: 8 1 2019
entrez: 24 11 2018
Statut: ppublish

Résumé

Myxoid liposarcoma (MLS) is a rare mesenchymal tumor that constitutes 10-20% of all liposarcomas. MLS is a translocation-related sarcoma (TRS) related to the chromosomal translocation t(12:16) (q13:p11), producing the FUS-CHOP oncoprotein that constitutes one of the main targets of trabectedin in MLS patients. It is known to be chemosensitive namely to trabectedin in contrast to other soft tissue sarcomas. The efficacy of this agent in MLS have been demonstrated in different settings including treatment-naïve and pre-treated patients with both locally advanced and metastatic disease. However, the benefits of trabectedin in MLS are shadowed by the limited activity of this drug in other subtypes of sarcomas that are enrolled within the same trials. This prompted us to screen the medical literature for clinical data that evaluates the efficacy and safety of trabectedin in MLS. In this review, we will summarize the available evidence for the applicability of trabectedin in MLS.

Identifiants

DOI: 10.1016/j.ctrv.2018.11.003 PMID: 30468937
pubmed: 30468937
pii: S0305-7372(18)30195-6
doi: 10.1016/j.ctrv.2018.11.003
pii:
doi:

Substances chimiques

Antineoplastic Agents, Alkylating 0
Trabectedin ID0YZQ2TCP

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-44

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Tarek Assi (T)

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France; Department of Oncology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon. Electronic address: tarek.assi@gustaveroussy.fr.

Joseph Kattan (J)

Department of Oncology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.

Elie El Rassy (E)

Department of Oncology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.

Charles Honore (C)

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

Sarah Dumont (S)

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

Olivier Mir (O)

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

Axel Le Cesne (A)

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Agents alcoylants › Antinéoplasiques alcoylants › A comprehensive review of the current evidence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A comprehensive review of the current evidence...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Liposarcome › Liposarcome myxoïde › A comprehensive review of the current evidence...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Tétrahydroisoquinoléines › Trabectédine › A comprehensive review of the current evidence...