T cells in the post-ischemic brain: Troopers or paramedics?
Brain ischemia
Cytokines
Inflammation
Lymphocyte
Neuroimmunology
Regeneration
Stroke
T cell
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
17
05
2018
revised:
04
10
2018
accepted:
12
11
2018
pubmed:
24
11
2018
medline:
30
11
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Recently, a critical role for T cells has also become more evident for the chronic phase after stroke in modulating delayed neuronal (dys-) function and recovery. Here, T cells may also affect various non-immunological pathways by interacting with brain-resident immune cells and modulating mechanisms such as neurogenesis and angiogenesis. This novel concept suggests T cells as potential therapeutic targets to modulate post-stroke regeneration.
Identifiants
pubmed: 30468953
pii: S0165-5728(18)30243-1
doi: 10.1016/j.jneuroim.2018.11.006
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-37Informations de copyright
Copyright © 2018. Published by Elsevier B.V.