Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective.
Cadmium
Copper
Dietary exposure
Iron
Land snails
Manganese
Journal
Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
21
01
2018
revised:
22
10
2018
accepted:
24
10
2018
pubmed:
24
11
2018
medline:
14
2
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.
Identifiants
pubmed: 30468972
pii: S1382-6689(18)30545-3
doi: 10.1016/j.etap.2018.10.005
pii:
doi:
Substances chimiques
Metals, Heavy
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-13Informations de copyright
Copyright © 2018. Published by Elsevier B.V.