Neural microvascular pericytes contribute to human adult neurogenesis.
RRID:AB_10013382
RRID:AB_10013383
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RRID:AB_1603338
RRID:AB_2251134
RRID:AB_2314899
RRID:AB_2341193
RRID:AB_300723
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RRID:AB_306863
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RRID:AB_448990
RRID:AB_476828
RRID:AB_732011
RRID:AB_732415
RRID:IMSR_JAX:003145
angiogenesis
human adult neurogenesis
pericytes
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
05
06
2018
revised:
06
10
2018
accepted:
17
10
2018
pubmed:
25
11
2018
medline:
25
7
2020
entrez:
25
11
2018
Statut:
ppublish
Résumé
Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface precision of ultrastructural resolution and anatomical simplicity of accessible human dental pulp neurogenic zone to address this conflict. We disclose a basal level of adult neurogenic activity characterized by glial invasion of terminal microvasculature followed by release of individual platelet-derived growth factor receptor-β mural pericytes and subsequent reprogramming into NeuN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
780-796Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE015272
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.