Vti Proteins: Beyond Endolysosomal Trafficking.

Animals Exocytosis / physiology Humans Lysosomes / metabolism Neurons / metabolism Protein Transport / physiology Qb-SNARE Proteins / metabolism Synaptic Transmission / physiology
SNARE proteins dense core vesicle exocytosis secretory vesicle vesicle biogenesis

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
10 11 2019
Historique:
received: 05 07 2018
revised: 08 11 2018
accepted: 09 11 2018
pubmed: 25 11 2018
medline: 23 9 2020
entrez: 25 11 2018
Statut: ppublish

Résumé

Vti proteins are conserved from yeast to humans and regulate intracellular membrane trafficking by providing one specific SNARE domain, the Qb SNARE, to the four helical SNARE bundle that drives membrane fusion. Two mammalian Vti genes, Vti1a and Vti1b are reported to regulate distinct aspects of endolysosomal trafficking and retrograde transport to the Golgi, but have also been implicated in synaptic vesicle secretion. In this review, we summarize the current evidence for the role of Vti proteins in intracellular trafficking in different cells. We propose that, despite some unique aspects, the two mammalian VTI genes have largely redundant functions in neurosecretory cells and recycle molecules required for the sorting of regulated cargo to the Golgi. Defects in this recycling also lead to defects in synaptic transmission and dense core vesicle secretion.

Identifiants

DOI: 10.1016/j.neuroscience.2018.11.014 PMID: 30471354
pubmed: 30471354
pii: S0306-4522(18)30738-3
doi: 10.1016/j.neuroscience.2018.11.014
pii:
doi:

Substances chimiques

Qb-SNARE Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

32-40

Informations de copyright

Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Javier Emperador-Melero (J)

Departments of Functional Genomics, Faculty of Exact Science, VUmc, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU Medical Center, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.

Ruud F Toonen (RF)

Departments of Functional Genomics, Faculty of Exact Science, VUmc, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU Medical Center, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.

Matthijs Verhage (M)

Departments of Functional Genomics, Faculty of Exact Science, VUmc, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU Medical Center, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands; Clinical Genetics, VUmc, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU Medical Center, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands. Electronic address: matthijs@cncr.vu.nl.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Cellules › Neurones › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › Protéines Q-SNARE › Protéines Qb-SNARE › Vti Proteins: Beyond Endolysosomal Trafficking.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Vti Proteins: Beyond Endolysosomal Trafficking.