Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos.

Acetylcholinesterase / genetics Animals Camphor / analogs & derivatives Embryo, Nonmammalian / drug effects Endocrine Disruptors / pharmacology Endocrine System / drug effects Enzyme Induction / drug effects Filtration / instrumentation Glutathione Transferase / genetics Oxidative Stress / drug effects Synaptic Transmission / drug effects Zebrafish / embryology
Aromatase Endocrine disruption Fish embryo test Heart rate Neurotransmission Oxidative stress

Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 04 07 2018
revised: 13 11 2018
accepted: 14 11 2018
pubmed: 26 11 2018
medline: 7 2 2019
entrez: 26 11 2018
Statut: ppublish

Résumé

Ultraviolet (UV) filters are widely used in personal care products and due to their lipophilicity these chemicals tend to bioaccumulate in the aquatic biota. 4-Methylbenzylidene camphor (4-MBC) is one of the most used UV-filters, and it is commonly detected in freshwater fish tissues. This substance is suspected to be an endocrine disruptor due to its interaction with Hypothalamus-Pituitary-Gonadal (HPG) and HP-Thyroid (HPT)-axis. The main objective of this study was to evaluate the effects of 4-MBC on apical endpoints, biochemical markers and on genes involved in endocrine pathways in Danio rerio. Zebrafish embryos were exposed to 4-MBC (0.083-0.77 mg/l) from 0 to 96 h post-fertilization (hpf). Hatching, heart rate and malformations were the apical endpoints assessed. Alterations on neurotransmission and oxidative stress were evaluated through acetylcholinesterase (AChE), catalase (CAT) and glutathione S-transferase (GST) enzymatic activities. Endocrine effects were analysed by the expression of genes involved in HPG and HPT-axis of embryos exposed 96 h to the EC

Identifiants

DOI: 10.1016/j.chemosphere.2018.11.096 PMID: 30472611
pubmed: 30472611
pii: S0045-6535(18)32203-3
doi: 10.1016/j.chemosphere.2018.11.096
pii:
doi:

Substances chimiques

Endocrine Disruptors 0
Camphor 76-22-2
enzacamene 8I3XWY40L9
Glutathione Transferase EC 2.5.1.18
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

273-281

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Carla Quintaneiro (C)

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: cquintaneiro@ua.pt.

Bruna Teixeira (B)

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

Juan L Benedé (JL)

Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, 46100, Burjassot, Valencia, Spain.

Alberto Chisvert (A)

Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, 46100, Burjassot, Valencia, Spain.

Amadeu M V M Soares (AMVM)

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

Marta S Monteiro (MS)

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Eucaryotes › Animaux › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Composés polycycliques › Composés pontés › Composés bicycliques pontés › Monoterpènes de type norbornane › Monoterpènes de type bornane › Camphre › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Perturbateurs endocriniens › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Système endocrine › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Induction enzymatique › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Phénomènes chimiques › Filtration › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Alkyl et aryl transferases › Glutathione transferase › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Toxicity effects of the organic UV-filter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Toxicity effects of the organic UV-filter...