Immune system responses in Parkinson's disease: Early and dynamic.
T-cells
alpha-synuclein
auto-antibodies
microglia
monocytes
neuroinflammation
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
08
2018
revised:
08
11
2018
accepted:
13
11
2018
pubmed:
27
11
2018
medline:
18
6
2020
entrez:
27
11
2018
Statut:
ppublish
Résumé
The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and death of dopamine-producing neurons in the ventral midbrain, the widespread intraneuronal aggregation of alpha-synuclein (α) in Lewy bodies and neurites, neuroinflammation, and gliosis. Signs of microglia activation in the PD brain postmortem as well as during disease development revealed by neuroimaging, implicate immune responses in the pathophysiology of the disease. Intensive research during the last two decades has advanced our understanding of the role of these responses in the disease process, yet many questions remain unanswered. A transformative finding in the field has been the confirmation that in vivo microglia are able to respond directly to pathological a-syn aggregates but also to neuronal dysfunction due to intraneuronal a-syn toxicity well in advance of neuronal death. In addition, clinical research and disease models have revealed the involvement of both the innate and adaptive immune systems. Indeed, the data suggest that PD leads not only to a microglia response, but also to a cellular and humoral peripheral immune response. Together, these findings compel us to consider a more holistic view of the immunological processes associated with the disease. Central and peripheral immune responses aimed at maintaining neuronal health will ultimately have consequences on neuronal survival. We will review here the most significant findings that have contributed to the current understanding of the immune response in PD, which is proposed to occur early, involve peripheral and brain immune cells, evolve as neuronal dysfunction progresses, and is likely to influence disease progression.
Identifiants
pubmed: 30474172
doi: 10.1111/ejn.14290
pmc: PMC6391192
mid: NIHMS998712
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-383Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092122
Pays : United States
Organisme : Aarhus Universitets Forskningsfond
Pays : International
Organisme : Parkinsonforeningen
Pays : International
Organisme : NIH HHS
ID : 3RF1AG051514-01
Pays : United States
Organisme : NIH HHS
ID : 5RF1AG057247
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051514
Pays : United States
Organisme : Michael J. Fox Foundation for Parkinson's Research
Pays : International
Organisme : NIH HHS
ID : 1RF1AG057247
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057247
Pays : United States
Informations de copyright
© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
JAMA Neurol. 2017 Jul 1;74(7):780-792
pubmed: 28586827
J Neurovirol. 1997 Apr;3(2):141-7
pubmed: 9111176
J Immunol. 2012 Jan 1;188(1):29-36
pubmed: 22079990
Neurobiol Dis. 2018 Jul;115:17-28
pubmed: 29501855
PLoS One. 2010 Jan 20;5(1):e8784
pubmed: 20098715
J Neurosci. 2006 Apr 12;26(15):3942-50
pubmed: 16611810
Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):897-909
pubmed: 20074453
NPJ Parkinsons Dis. 2017 Mar 28;3:11
pubmed: 28649611
Nat Commun. 2013;4:1562
pubmed: 23463005
Neuroscience. 2015 Aug 27;302:89-102
pubmed: 25450953
Mol Neurodegener. 2017 Jun 7;12(1):44
pubmed: 28592329
Brain. 2018 Jun 1;141(6):1753-1769
pubmed: 29800472
Mol Neurodegener. 2017 Jul 4;12(1):52
pubmed: 28676095
Neurobiol Dis. 2015 Nov;83:90-9
pubmed: 26342897
J Neurosci. 2016 Sep 7;36(36):9375-90
pubmed: 27605613
J Immunol. 2003 Sep 15;171(6):3034-46
pubmed: 12960329
JAMA Neurol. 2013 Jul;70(7):852-8
pubmed: 23699752
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1926-35
pubmed: 25825709
PLoS One. 2013 Aug 23;8(8):e71634
pubmed: 24058406
PLoS One. 2010 Oct 26;5(10):e13481
pubmed: 21048992
JAMA Neurol. 2018 Oct 1;75(10):1206-1214
pubmed: 29913017
J Neurosci. 2012 Sep 26;32(39):13454-69
pubmed: 23015436
Biochem Biophys Res Commun. 2009 Mar 27;381(1):39-43
pubmed: 19351591
Exp Neurol. 2012 Oct;237(2):318-34
pubmed: 22750327
Acta Neuropathol. 2016 Mar;131(3):379-91
pubmed: 26576561
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Lancet Neurol. 2017 Oct;16(10):769-771
pubmed: 28807669
Mov Disord. 2017 Jul;32(7):1066-1073
pubmed: 28548309
Nat Genet. 2010 Sep;42(9):781-5
pubmed: 20711177
Acta Neuropathol. 2017 Feb;133(2):303-319
pubmed: 27888296
J Neuroimmunol. 2017 Sep 15;310:26-31
pubmed: 28778441
J Neurosci. 2018 Jan 24;38(4):1000-1014
pubmed: 29246926
Neuroimmunomodulation. 2014;21(2-3):88-94
pubmed: 24557040
J Neural Transm Suppl. 2000;(58):143-51
pubmed: 11128604
PLoS One. 2012;7(10):e47387
pubmed: 23082161
Neurosci Lett. 1994 Jan 3;165(1-2):208-10
pubmed: 8015728
Mol Neurodegener. 2015 Mar 19;10:10
pubmed: 25886309
J Neuropathol Exp Neurol. 2008 Dec;67(12):1149-58
pubmed: 19018246
J Neurosci. 2013 Jun 5;33(23):9592-600
pubmed: 23739956
Brain Res. 2007 Jan 12;1128(1):1-11
pubmed: 17126305
Parkinsonism Relat Disord. 2005 Dec;11(8):493-8
pubmed: 16154792
J Neural Transm (Vienna). 2011 May;118(5):795-808
pubmed: 21552986
J Neuroinflammation. 2017 Mar 21;14(1):60
pubmed: 28320442
Nature. 2018 Sep;561(7722):258-262
pubmed: 30135585
J Immunol. 2010 Mar 1;184(5):2261-71
pubmed: 20118279
Ann Neurol. 2005 Feb;57(2):168-75
pubmed: 15668962
Trends Immunol. 2007 Mar;28(3):138-45
pubmed: 17276138
Mov Disord. 2011 Jan;26(1):6-17
pubmed: 21322014
Ann Nucl Med. 2016 Oct;30(8):579-87
pubmed: 27299437
J Neuroinflammation. 2007 Jan 04;4:2
pubmed: 17204153
Biochem Soc Trans. 2017 Feb 8;45(1):131-139
pubmed: 28202666
Science. 2016 Sep 30;353(6307):
pubmed: 27708076
J Neuroimmune Pharmacol. 2008 Jun;3(2):59-74
pubmed: 18202920
Exp Neurol. 2018 Feb;300:179-187
pubmed: 29155051
Acta Neurol Scand. 1994 Sep;90(3):160-6
pubmed: 7847055
Int J Neurosci. 2013 May;123(5):329-32
pubmed: 23270425
Neurology. 2011 Mar 8;76(10):863-9
pubmed: 21368281
PLoS One. 2015 Oct 15;10(10):e0140566
pubmed: 26469270
Mol Ther. 2015 Jan;23(1):17-23
pubmed: 25195598
J Neuroimmunol. 2012 Nov 15;252(1-2):95-9
pubmed: 22910543
J Neuroimmunol. 2011 Apr;233(1-2):221-7
pubmed: 21239064
Mol Cell Neurosci. 2000 Dec;16(6):724-39
pubmed: 11124893
J Exp Med. 1995 Jun 1;181(6):2161-9
pubmed: 7760004
ASN Neuro. 2013 Apr 30;5(2):113-39
pubmed: 23506036
Can J Neurol Sci. 2012 Jan;39(1):58-64
pubmed: 22384497
J Parkinsons Dis. 2013;3(4):493-514
pubmed: 24275605
Brain Behav Immun. 2013 Jan;27(1):91-100
pubmed: 23044176
J Neuroinflammation. 2012 Nov 27;9:259
pubmed: 23186369
Int J Immunopharmacol. 1992 Jul;14(5):739-46
pubmed: 1512070
Psychosomatics. 2010 Nov-Dec;51(6):474-9
pubmed: 21051678
Rev Neurol. 2007 Dec 16-31;45(12):725-8
pubmed: 18075986
Mov Disord. 2018 May;33(5):793-804
pubmed: 29572994
Immunobiology. 2016 Feb;221(2):333-40
pubmed: 26517968
Bull Exp Biol Med. 2017 Apr;162(6):734-737
pubmed: 28429209
Mov Disord. 2013 Mar;28(3):392-5
pubmed: 23401086
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Neurochem Res. 2009 Aug;34(8):1401-4
pubmed: 19214748
Immunity. 2000 Aug;13(2):233-42
pubmed: 10981966
Front Mol Neurosci. 2018 Feb 13;11:36
pubmed: 29497361
Nat Rev Immunol. 2014 Feb;14(2):94-108
pubmed: 24445665
Brain Behav Immun. 2009 Jan;23(1):55-63
pubmed: 18678243
Mol Cells. 2000 Feb 29;10(1):65-70
pubmed: 10774749
Cell Mol Neurobiol. 2017 Jan;37(1):121-131
pubmed: 26961542
J Immunol. 2010 Jul 1;185(1):615-23
pubmed: 20511551
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3413-8
pubmed: 15716361
Glia. 2018 Jan;66(1):191-205
pubmed: 29024008
Arch Neurol. 2001 Oct;58(10):1580-3
pubmed: 11594915
Cell Rep. 2018 Jan 2;22(1):136-148
pubmed: 29298416
J Leukoc Biol. 2007 Nov;82(5):1083-94
pubmed: 17675560
Nat Commun. 2014 Apr 16;5:3633
pubmed: 24736453
Exp Neurol. 2006 Feb;197(2):275-83
pubmed: 16336966
J Leukoc Biol. 2017 Oct;102(4):1093-1102
pubmed: 28751472
J Parkinsons Dis. 2015;5(1):1-19
pubmed: 25588354
J Neurosci. 2006 Oct 11;26(41):10558-63
pubmed: 17035541
J Neuroimmunol. 2001 Feb 1;113(1):146-52
pubmed: 11137586
Free Radic Biol Med. 2011 May 1;50(9):1094-106
pubmed: 21295135
J Clin Invest. 2009 Jan;119(1):182-92
pubmed: 19104149
Acta Neuropathol Commun. 2017 Nov 21;5(1):85
pubmed: 29162163
J Neuroinflammation. 2016 Jun 30;13(1):174
pubmed: 27364890
Am J Pathol. 2011 Aug;179(2):954-63
pubmed: 21801874
Nat Neurosci. 2006 Jul;9(7):917-24
pubmed: 16732273
Mov Disord. 2017 May;32(5):739-749
pubmed: 28195358
Mov Disord. 2015 Sep;30(10):1351-60
pubmed: 26179554
J Biol Chem. 2011 Oct 7;286(40):35104-18
pubmed: 21846727
Acta Neuropathol Commun. 2014 Aug 07;2:90
pubmed: 25099483
J Neuroimmune Pharmacol. 2012 Dec;7(4):927-38
pubmed: 23054369
Neuronal Signal. 2018 Apr 16;2(2):NS20170166
pubmed: 32714585
J Neurochem. 2009 Jun;109(5):1483-96
pubmed: 19457162
J Neurosci. 2008 Oct 22;28(43):10825-34
pubmed: 18945890
Nature. 2017 Jun 29;546(7660):656-661
pubmed: 28636593
PLoS One. 2011;6(8):e23660
pubmed: 21858193
Brain. 2005 Nov;128(Pt 11):2665-74
pubmed: 16219675
Neurology. 2010 Mar 23;74(12):995-1002
pubmed: 20308684
Neurochem Res. 2006 Jan;31(1):85-94
pubmed: 16475001
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Acta Neuropathol. 2014 Nov;128(5):651-63
pubmed: 25284487
Environ Health Perspect. 2011 Jun;119(6):807-14
pubmed: 21245015
Curr Neuropharmacol. 2016;14(7):732-42
pubmed: 27640518
Neurology. 2013 Jan 8;80(2):169-75
pubmed: 23255825
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14063-8
pubmed: 19667183
Neurobiol Aging. 2017 Jun;54:175-186
pubmed: 28390825
PLoS One. 2015 Nov 05;10(11):e0142164
pubmed: 26539989
J Neuropathol Exp Neurol. 2013 Jul;72(7):624-45
pubmed: 23771222
J Neuroinflammation. 2017 Aug 18;14(1):164
pubmed: 28821274
Glia. 2013 Mar;61(3):349-60
pubmed: 23108585
Cell. 2016 Jul 14;166(2):314-327
pubmed: 27345367
J Neuroinflammation. 2011 Jan 25;8:9
pubmed: 21266082
Acta Neuropathol. 2003 Dec;106(6):518-26
pubmed: 14513261
Biomed Pharmacother. 1999 Apr;53(3):141-5
pubmed: 10349502
Neurobiol Aging. 2008 Nov;29(11):1690-701
pubmed: 17537546
Nat Commun. 2018 Mar 26;9(1):1228
pubmed: 29581545
Neurochem Res. 2010 Apr;35(4):540-7
pubmed: 19924532
Nat Rev Immunol. 2018 Apr;18(4):225-242
pubmed: 29151590
J Neurol Sci. 1985 Jul;69(3):121-31
pubmed: 3161999
Neurology. 1988 Aug;38(8):1285-91
pubmed: 3399080
PLoS One. 2011 Apr 25;6(4):e18513
pubmed: 21541339
Eur J Neurol. 2017 Feb;24(2):427-e6
pubmed: 28102045
Neurosci Lett. 1994 Oct 24;180(2):147-50
pubmed: 7700568
ISRN Neurol. 2011;2011:476158
pubmed: 22389821
Biochem Biophys Res Commun. 2008 Aug 1;372(3):423-8
pubmed: 18492487
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173
pubmed: 29760073
J Neurosci. 2010 May 19;30(20):6838-51
pubmed: 20484626
Neurobiol Aging. 2003 Mar-Apr;24(2):245-58
pubmed: 12498958
Neuropsychopharmacology. 2013 May;38(6):938-49
pubmed: 23303049
J Neuroinflammation. 2018 Jul 12;15(1):205
pubmed: 30001736
Heliyon. 2018 Feb 01;4(1):e00513
pubmed: 29560431
Neuroscience. 1996 May;72(2):355-63
pubmed: 8737406
Med Sci Monit. 2016 May 23;22:1733-41
pubmed: 27213506
Glia. 2007 Aug 15;55(11):1178-88
pubmed: 17600340
J Neurosci. 2012 Oct 17;32(42):14592-601
pubmed: 23077045
Glia. 2008 Aug 15;56(11):1215-23
pubmed: 18449945
Acta Neuropathol Commun. 2014 Feb 14;2:21
pubmed: 24528486
Science. 2016 Aug 19;353(6301):aad8670
pubmed: 27338705
Ann Clin Transl Neurol. 2016 Jun 16;3(8):588-606
pubmed: 27606342
Biochim Biophys Acta. 2016 Mar;1862(3):329-38
pubmed: 26584587
J Neuroimmunol. 2016 Feb 15;291:110-4
pubmed: 26857504
Neurosci Lett. 1995 Jun 30;193(2):129-32
pubmed: 7478158
J Neuroinflammation. 2011 Nov 28;8:166
pubmed: 22122884
Parkinsonism Relat Disord. 2013 Jan;19(1):47-52
pubmed: 22841687
J Neuroinflammation. 2016 Apr 07;13(1):74
pubmed: 27055651
J Neurochem. 2016 Oct;139 Suppl 1:59-74
pubmed: 27090875
Dev Neurobiol. 2018 Jun;78(6):593-603
pubmed: 29271125
Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S200-4
pubmed: 20082990
Mov Disord. 2015 Mar;30(3):350-8
pubmed: 25476529
Acta Neurol Scand. 1998 Aug;98(2):142-4
pubmed: 9724016
Front Neurosci. 2014 Aug 21;8:235
pubmed: 25191216
Sci Transl Med. 2018 Jan 10;10(423):
pubmed: 29321258
PLoS One. 2016 Sep 13;11(9):e0162717
pubmed: 27622765
Mov Disord. 2012 Aug;27(9):1111-7
pubmed: 22753266
Prog Neurobiol. 2019 Jun;177:73-93
pubmed: 30219247
Redox Biol. 2018 Apr;14:600-608
pubmed: 29154191
Acta Neuropathol Commun. 2017 Jan 13;5(1):7
pubmed: 28086964
J Virol. 2015 Dec 30;90(6):2767-82
pubmed: 26719256
FASEB J. 2016 Feb;30(2):564-77
pubmed: 26443817
Mol Neurobiol. 2018 Jan;55(1):619-632
pubmed: 27975175
Biochem Biophys Res Commun. 2016 Oct 28;479(4):881-886
pubmed: 27666480
Immunobiology. 2014 Nov;219(11):836-44
pubmed: 25092570
Neurosci Lett. 1994 May 19;172(1-2):151-4
pubmed: 8084523
Sci Transl Med. 2012 Feb 15;4(121):121ps3
pubmed: 22344685
Clin Neurol Neurosurg. 2018 Dec;175:16-24
pubmed: 30308319
Bull Exp Biol Med. 2002 Jan;133(1):81-3
pubmed: 12170314
Immunobiology. 2006;211(6-8):419-25
pubmed: 16920481
Neuroscience. 2012 Apr 19;208:85-96
pubmed: 22342967
J Neurosci. 2014 Jul 9;34(28):9441-54
pubmed: 25009275
FASEB J. 2005 Apr;19(6):533-42
pubmed: 15791003
PLoS One. 2015 Feb 06;10(2):e0116841
pubmed: 25658425
Neurobiol Aging. 2008 May;29(5):739-52
pubmed: 17166628
NPJ Parkinsons Dis. 2015;1:
pubmed: 27148593
Sci Rep. 2017 Jul 25;7(1):6363
pubmed: 28743955
NPJ Parkinsons Dis. 2017 Jan 11;3:3
pubmed: 28649603
Acta Neurol Scand. 2000 Mar;101(3):159-64
pubmed: 10705937
Sci Signal. 2015 May 12;8(376):ra45
pubmed: 25969543
J Neuroinflammation. 2005 Jun 03;2:14
pubmed: 15935098
JAMA Neurol. 2016 Nov 01;73(11):1316-1324
pubmed: 27668667
Neurobiol Dis. 2006 Feb;21(2):404-12
pubmed: 16182554
Lancet Neurol. 2017 Oct;16(10):789-796
pubmed: 28684245