Risk factors for graft loss in kidney transplant recipients with g3 glomerulitis: A single-center experience .
Journal
Clinical nephrology
ISSN: 0301-0430
Titre abrégé: Clin Nephrol
Pays: Germany
ID NLM: 0364441
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
accepted:
16
01
2019
pubmed:
27
11
2018
medline:
14
3
2019
entrez:
27
11
2018
Statut:
ppublish
Résumé
Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined. We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study. The diagnosis of g3 glomerulonephritis was made 6.1 ± 6.6 years after transplant. The majority of patients were Caucasian (86%), male (65%), and received basiliximab induction (54%). At the time of biopsy, all were on triple therapy with tacrolimus, mycophenolate, and prednisone. Mean serum creatinine (Scr) was 2.85 ± 2.1 mg/dL. Notably, 20 (54%) were positive for donor-specific antibodies (DSA Severe glomerulitis was associated with a high prevalence of TG and graft loss at 4 years. Live donor status, kidney function (Scr), and tubular injury (t- and ct-scores) were independently associated with graft loss. Interventional mechanistic clinical trials are needed to better understand the pathogenesis and outcomes of g3 glomerulitis.
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Sections du résumé
BACKGROUND
BACKGROUND
Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined.
MATERIALS AND METHODS
METHODS
We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study.
RESULTS
RESULTS
The diagnosis of g3 glomerulonephritis was made 6.1 ± 6.6 years after transplant. The majority of patients were Caucasian (86%), male (65%), and received basiliximab induction (54%). At the time of biopsy, all were on triple therapy with tacrolimus, mycophenolate, and prednisone. Mean serum creatinine (Scr) was 2.85 ± 2.1 mg/dL. Notably, 20 (54%) were positive for donor-specific antibodies (DSA
CONCLUSION
CONCLUSIONS
Severe glomerulitis was associated with a high prevalence of TG and graft loss at 4 years. Live donor status, kidney function (Scr), and tubular injury (t- and ct-scores) were independently associated with graft loss. Interventional mechanistic clinical trials are needed to better understand the pathogenesis and outcomes of g3 glomerulitis.
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Identifiants
pubmed: 30474594
pii: 17810
doi: 10.5414/CN109484
doi:
Substances chimiques
Creatine
MU72812GK0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM