Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds.
Alzheimer’s disease
clinical trial
cognitive decline
cognitive training
dementia
depression
non-pharmacological
nutrition
physical activity
randomized controlled trial
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
27
11
2018
medline:
21
10
2020
entrez:
27
11
2018
Statut:
ppublish
Résumé
Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.
Sections du résumé
BACKGROUND
Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort.
METHODS
MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial.
DISCUSSION
MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.
Identifiants
pubmed: 30475762
pii: JAD180572
doi: 10.3233/JAD-180572
pmc: PMC6700632
doi:
Banques de données
ANZCTR
['ACTRN12618000851268']
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S221-S237Références
J Affect Disord. 2014 Aug;165:45-52
pubmed: 24882176
Lancet. 2015 Oct 24;386(10004):1625-6
pubmed: 26595628
J Anxiety Disord. 2017 Mar;46:25-34
pubmed: 27396841
Med Sci Sports Exerc. 2009 Jul;41(7):1510-30
pubmed: 19516148
N Engl J Med. 2013 Apr 4;368(14):1279-90
pubmed: 23432189
J Nutr. 2011 Jun;141(6):1140-5
pubmed: 21508208
Biochem Pharmacol. 2014 Apr 15;88(4):661-70
pubmed: 24418410
Lancet Neurol. 2014 Aug;13(8):788-94
pubmed: 25030513
J Stat Softw. 2013 Sep;54(10):
pubmed: 24403868
Ageing Res Rev. 2017 Nov;40:75-83
pubmed: 28912076
Public Health Nutr. 2006 Sep;9(6):755-62
pubmed: 16925881
Br J Sports Med. 1996 Sep;30(3):209-12
pubmed: 8889112
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Arch Intern Med. 2006 May 22;166(10):1092-7
pubmed: 16717171
Int J Epidemiol. 2008 Oct;37(5):941-7
pubmed: 17881411
J Am Geriatr Soc. 2017 Mar;65(3):550-559
pubmed: 28304092
JAMA Intern Med. 2015 Jul;175(7):1094-1103
pubmed: 25961184
Prev Sci. 2013 Aug;14(4):411-21
pubmed: 23319292
Am J Clin Nutr. 2018 Mar 1;107(3):389-404
pubmed: 29566197
Lancet. 2015 Jun 6;385(9984):2255-63
pubmed: 25771249
PLoS Med. 2014 Nov 18;11(11):e1001756
pubmed: 25405755
Med Sci Sports Exerc. 1997 Jun;29(6 Suppl):S1-205
pubmed: 9243481
J Pain Palliat Care Pharmacother. 2015 Jun;29(2):133-9
pubmed: 26095483
Psychol Med. 2013 Dec;43(12):2635-48
pubmed: 23419552
Ann Neurol. 2013 Oct;74(4):580-91
pubmed: 23720230
Psychol Med. 2007 Jul;37(7):1015-25
pubmed: 17112402
Lancet Neurol. 2011 Sep;10(9):819-28
pubmed: 21775213
J Geriatr Psychiatry Neurol. 2013 Dec;26(4):244-50
pubmed: 24212244
BMJ. 2005 Apr 9;330(7495):843
pubmed: 15817555
J Am Med Dir Assoc. 2014 Dec;15(12):873-80
pubmed: 25444575
Lancet. 2017 Dec 16;390(10113):2673-2734
pubmed: 28735855
Br J Nutr. 2018 Nov;120(10):1189-1200
pubmed: 30401000
Disabil Rehabil. 2014;36(24):2091-100
pubmed: 24564358
Public Health Nutr. 2014 Dec;17(12):2769-82
pubmed: 24476641
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Ageing Res Rev. 2014 May;15:61-75
pubmed: 24632497
Lancet Neurol. 2017 May;16(5):377-389
pubmed: 28359749
Alzheimers Dement (N Y). 2016 Apr 03;2(2):93-98
pubmed: 29067296
Age Ageing. 1997 Jul;26(4):253-60
pubmed: 9271287
J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1233-41
pubmed: 25829520
J Neurol Sci. 2012 Nov 15;322(1-2):64-70
pubmed: 22818266
Behav Brain Res. 2015 Dec 15;295:64-70
pubmed: 25591472
Alzheimers Res Ther. 2017 Feb 17;9(1):11
pubmed: 28212674
Lancet. 2005 Dec 17;366(9503):2112-7
pubmed: 16360788
Lancet. 2016 Aug 20;388(10046):797-805
pubmed: 27474376
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Transl Psychiatry. 2012 Nov 20;2:e191
pubmed: 23168991
Psychol Med. 2002 Aug;32(6):959-76
pubmed: 12214795