Thymus machinery for T-cell selection.
central tolerance
cortical thymic epithelial cell
medullary thymic epithelial cell
positive selection
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
05 03 2019
05 03 2019
Historique:
received:
05
11
2018
accepted:
20
11
2018
pubmed:
27
11
2018
medline:
6
2
2020
entrez:
27
11
2018
Statut:
ppublish
Résumé
An immunocompetent and self-tolerant pool of naive T cells is formed in the thymus through the process of repertoire selection. T cells that are potentially capable of responding to foreign antigens are positively selected in the thymic cortex and are further selected in the thymic medulla to help prevent self-reactivity. The affinity between T-cell antigen receptors expressed by newly generated T cells and self-peptide-major histocompatibility complexes displayed in the thymic microenvironments plays a key role in determining the fate of developing T cells during thymic selection. Recent advances in our knowledge of the biology of thymic epithelial cells have revealed unique machinery that contributes to positive and negative selection in the thymus. In this article, we summarize recent findings on thymic T-cell selection, focusing on the machinery unique to thymic epithelial cells.
Identifiants
pubmed: 30476234
pii: 5200722
doi: 10.1093/intimm/dxy081
pmc: PMC6400048
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-125Informations de copyright
Published by Oxford University Press on behalf of The Japanese Society for Immunology 2018.
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