CXCR6 protects from inflammation and fibrosis in NEMO


Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 03 07 2018
revised: 16 10 2018
accepted: 22 11 2018
pubmed: 27 11 2018
medline: 19 9 2019
entrez: 27 11 2018
Statut: ppublish

Résumé

Chronic inflammation in the liver provokes fibrosis and, on long-term, carcinogenesis. This sequence is prototypically recapitulated in mice with hepatocyte-specific knock-out of the NF-κB essential modulator (NEMO), termed NEMO

Identifiants

pubmed: 30476545
pii: S0925-4439(18)30482-4
doi: 10.1016/j.bbadis.2018.11.020
pii:
doi:

Substances chimiques

Intracellular Signaling Peptides and Proteins 0
NEMO protein, mouse 0
Receptors, CXCR6 0
Tumor Necrosis Factor-alpha 0
Cytochrome P-450 CYP4A EC 1.14.15.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

391-402

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Anke Liepelt (A)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Alexander Wehr (A)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Marlene Kohlhepp (M)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Jana C Mossanen (JC)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany; Department of Intensive and Intermediate Care, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Karina Kreggenwinkel (K)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Bernd Denecke (B)

Chip Facility, IZKF Aachen, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.

Ivan G Costa (IG)

IZKF Computational Biology Research Group, University Hospital, Pauwelsstraße 19, RWTH Aachen University, 52074 Aachen, Germany.

Tom Luedde (T)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Christian Trautwein (C)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Frank Tacke (F)

Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. Electronic address: frank.tacke@gmx.net.

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Classifications MeSH