Impact of hypobaric flight simulation on walking distance and oxygenation in COPD patients.
6-MIN walking test
Altitude – respiration
COPD
Hypoxemia
Oxygen desaturation
Oxygen supplementation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
21
09
2018
revised:
19
11
2018
accepted:
22
11
2018
pubmed:
27
11
2018
medline:
4
4
2019
entrez:
27
11
2018
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is a disease that compromises fitness to fly. To investigate, whether hypobaric mid-distance flight simulation limits exercise endurance in COPD patients. Patients with COPD GOLD stages 2-4 were challenged by hypobaric flight simulation. Patients completed 6-minute walking distances before and after the simulation test. Pulse oximetry and Borg dyspnea scale were measured every 30 min during the test. Thirty-five patients were included in the study. The distance of the 6-min walking exercise decreased from 343 ± 93 m to 308 ± 101 m (p < 0.0001). The oxygen saturation nadir for the whole group was 72.2% ± 9.1%. The Borg-dypnea-score did not correlate with oxygen desaturation (R-square 0.009, p > 0.05). A 3-h hypobaric flight simulation compromises exercise endurance by 35 m or 10%. Hypoxia was well tolerated and more liberal recommendations might by justifiable since hypoxemia appears to be unrelated to dyspnea perception.
Sections du résumé
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a disease that compromises fitness to fly.
OBJECTIVE
To investigate, whether hypobaric mid-distance flight simulation limits exercise endurance in COPD patients.
METHODS
Patients with COPD GOLD stages 2-4 were challenged by hypobaric flight simulation. Patients completed 6-minute walking distances before and after the simulation test. Pulse oximetry and Borg dyspnea scale were measured every 30 min during the test.
RESULTS
Thirty-five patients were included in the study. The distance of the 6-min walking exercise decreased from 343 ± 93 m to 308 ± 101 m (p < 0.0001). The oxygen saturation nadir for the whole group was 72.2% ± 9.1%. The Borg-dypnea-score did not correlate with oxygen desaturation (R-square 0.009, p > 0.05).
CONCLUSIONS
A 3-h hypobaric flight simulation compromises exercise endurance by 35 m or 10%. Hypoxia was well tolerated and more liberal recommendations might by justifiable since hypoxemia appears to be unrelated to dyspnea perception.
Identifiants
pubmed: 30476554
pii: S1569-9048(18)30304-5
doi: 10.1016/j.resp.2018.11.010
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.