Dissociable Disruptions in Thalamic and Hippocampal Resting-State Functional Connectivity in Youth with 22q11.2 Deletions.
Adolescent
Adult
Aging
/ psychology
Child
Connectome
DiGeorge Syndrome
/ diagnostic imaging
Female
Gray Matter
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Nerve Net
/ diagnostic imaging
Neural Pathways
/ diagnostic imaging
Neuroimaging
Sensorimotor Cortex
/ diagnostic imaging
Thalamus
/ diagnostic imaging
Young Adult
22q11
connectivity
fMRI
hippocampus
networks
thalamus
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
07
12
2017
revised:
14
11
2018
accepted:
15
11
2018
pubmed:
28
11
2018
medline:
18
12
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
The 22q11.2 deletion syndrome (22q11DS) is a recurrent copy number variant with high penetrance for developmental neuropsychiatric disorders. Study of individuals with 22q11DS therefore may offer key insights into neural mechanisms underlying such complex illnesses. Resting-state functional connectivity MRI studies in idiopathic schizophrenia have consistently revealed disruption of thalamic and hippocampal circuitry. Here, we sought to test whether this circuitry is similarly disrupted in the context of this genetic high-risk condition. To this end, resting-state functional connectivity patterns were assessed in a sample of human youth with 22q11DS (
Identifiants
pubmed: 30478034
pii: JNEUROSCI.3470-17.2018
doi: 10.1523/JNEUROSCI.3470-17.2018
pmc: PMC6381244
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1319Subventions
Organisme : NIMH NIH HHS
ID : T32 MH073526
Pays : United States
Organisme : NIH HHS
ID : DP5 OD012109
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087101
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112189
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085953
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108590
Pays : United States
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/391302-19$15.00/0.
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