The Core and Holoenzyme Forms of RNA Polymerase from

RNA polymerase bacterial transcription conformational change cryo-electron microscopy mycobacteria protein structure transcription initiation factor

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
15 02 2019
Historique:
received: 20 09 2018
accepted: 20 11 2018
pubmed: 28 11 2018
medline: 23 10 2019
entrez: 28 11 2018
Statut: epublish

Résumé

Bacterial RNA polymerase (RNAP) is essential for gene expression and as such is a valid drug target. Hence, it is imperative to know its structure and dynamics. Here, we present two as-yet-unreported forms of

Identifiants

pubmed: 30478083
pii: JB.00583-18
doi: 10.1128/JB.00583-18
pmc: PMC6351736
pii:
doi:

Substances chimiques

Holoenzymes 0
DNA-Directed RNA Polymerases EC 2.7.7.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MC_EX_G0901534
Pays : United Kingdom

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Tomáš Kouba (T)

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom tkouba@embl.fr krasny@biomed.cas.cz.

Jiří Pospíšil (J)

Laboratory of Microbial Genetics and Gene Expression, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.

Jarmila Hnilicová (J)

Laboratory of Microbial Genetics and Gene Expression, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Hana Šanderová (H)

Laboratory of Microbial Genetics and Gene Expression, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Ivan Barvík (I)

Division of Biomolecular Physics, Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic.

Libor Krásný (L)

Laboratory of Microbial Genetics and Gene Expression, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic tkouba@embl.fr krasny@biomed.cas.cz.

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