Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.
Parkinson disease
alpha-synuclein (α-synuclein)
biosensor
fibril
fluorescence resonance energy transfer (FRET)
multiple system atrophy
neurodegeneration
prion strain
protein aggregation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
19
06
2018
revised:
20
11
2018
pubmed:
28
11
2018
medline:
17
4
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in neurons and glial cells. These disorders and other neurodegenerative diseases may progress via prion-like mechanisms. The prion model of propagation predicts the existence of "strains" that link pathological aggregate structure and neuropathology. Prion strains are aggregated conformers that stably propagate
Identifiants
pubmed: 30478174
pii: S0021-9258(20)40037-7
doi: 10.1074/jbc.RA118.004471
pmc: PMC6341389
doi:
Substances chimiques
SNCA protein, human
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1045-1058Subventions
Organisme : NINDS NIH HHS
ID : R01 NS075321
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097799
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001996
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000116
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS110436
Pays : United States
Informations de copyright
© 2019 Yamasaki et al.
Références
Nat Cell Biol. 2002 Feb;4(2):160-4
pubmed: 11813001
Neuropathology. 2015 Aug;35(4):390-400
pubmed: 25964057
Nature. 1997 Aug 28;388(6645):839-40
pubmed: 9278044
J Comp Pathol. 1973 Jan;83(1):29-40
pubmed: 4199908
Int J Biochem Cell Biol. 2008;40(9):1835-49
pubmed: 18291704
Nat Commun. 2013;4:2575
pubmed: 24108358
Genet Res. 1969 Apr;13(2):213-25
pubmed: 4978935
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10323-8
pubmed: 24982139
Nat Rev Neurosci. 2010 Mar;11(3):155-9
pubmed: 20029438
Brain. 2013 Apr;136(Pt 4):1128-38
pubmed: 23466394
Neurosci Lett. 1998 Jul 31;251(3):205-8
pubmed: 9726379
J Neurol Sci. 1989 Dec;94(1-3):79-100
pubmed: 2559165
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4376-85
pubmed: 25261551
J Biol Chem. 2009 May 8;284(19):12845-52
pubmed: 19282288
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5
pubmed: 19651612
Neurobiol Dis. 2011 Sep;43(3):552-7
pubmed: 21600984
Cell Tissue Res. 2004 Oct;318(1):121-34
pubmed: 15338272
Science. 2012 Nov 16;338(6109):949-53
pubmed: 23161999
J Biol Chem. 1999 Jul 9;274(28):19509-12
pubmed: 10391881
EMBO Rep. 2013 Nov;14(11):1017-22
pubmed: 23999102
Ann Neurol. 2014 Mar;75(3):351-62
pubmed: 24243558
Science. 2016 Sep 30;353(6307):
pubmed: 27708076
Cell. 2013 Jul 3;154(1):103-17
pubmed: 23827677
J Parkinsons Dis. 2015;5(2):217-27
pubmed: 25757830
J Med Chem. 2015 Aug 13;58(15):6002-17
pubmed: 26177091
J Exp Med. 2012 May 7;209(5):975-86
pubmed: 22508839
Lancet Neurol. 2009 Dec;8(12):1172-8
pubmed: 19909915
Acta Neuropathol Commun. 2013 Jul 17;1:38
pubmed: 24252149
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83
pubmed: 9811807
Neuron. 2014 Jun 18;82(6):1271-88
pubmed: 24857020
PLoS One. 2012;7(6):e39465
pubmed: 22737239
J Vis Exp. 2015 Dec 08;(106):e53205
pubmed: 26710240
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58
pubmed: 26286986
Nat Rev Mol Cell Biol. 2007 Jul;8(7):552-61
pubmed: 17585315
Science. 2007 Nov 9;318(5852):930-6
pubmed: 17991853
Nat Med. 2008 May;14(5):501-3
pubmed: 18391963
PLoS One. 2013;8(2):e55031
pubmed: 23405108
Science. 2006 Sep 22;313(5794):1781-4
pubmed: 16990547
Nature. 2015 Jun 18;522(7556):340-4
pubmed: 26061766
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17
pubmed: 26324905
J Neurosci. 2005 Jun 22;25(25):6016-24
pubmed: 15976091
Nat Med. 2014 Feb;20(2):130-8
pubmed: 24504409
J Neurochem. 2016 Oct;139 Suppl 1:256-274
pubmed: 26924014
Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6
pubmed: 19892735
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3138-47
pubmed: 23898162
Science. 2004 Aug 13;305(5686):1010-3
pubmed: 15310905
J Clin Invest. 2011 Feb;121(2):715-25
pubmed: 21245577
Ann Neurol. 2012 Oct;72(4):517-24
pubmed: 23109146
Nature. 2018 May;557(7706):558-563
pubmed: 29743672
Nat Med. 2008 May;14(5):504-6
pubmed: 18391962
Exp Neurol. 2004 Jun;187(2):279-88
pubmed: 15144854
Neuron. 2016 Feb 3;89(3):433-48
pubmed: 26844828
Prion. 2013 Mar-Apr;7(2):99-108
pubmed: 23357828
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19555-60
pubmed: 24218576
J Biol Chem. 2002 Dec 13;277(50):49071-6
pubmed: 12377775
J Neurosci. 2011 Oct 12;31(41):14488-95
pubmed: 21994365
ACS Chem Biol. 2015 May 15;10(5):1269-77
pubmed: 25695325