Models of immune selection for multi-locus antigenic diversity of pathogens.
Journal
Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
28
11
2018
medline:
18
12
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
It is well accepted that pathogens can evade recognition and elimination by the host immune system by varying their antigenic targets. Thus, it has become a truism that host immunity is a major driver and determinant of the antigenic diversity of pathogens. However, it remains puzzling how host immunity selects for antigenic diversity at the level of the pathogen population, given that hosts have acquired immune responses to multiple antigens of most pathogens - sometimes through multiple effectors of both humoral and cellular immunity. In this Opinion article, we address this puzzle and the related question of why pathogens often have diversity at multiple antigenic loci. Here, we describe five hypotheses to explain the polymorphism of multiple antigens in a single pathogen species and highlight research relevant to our current models of thinking about multi-locus antigenic diversity.
Identifiants
pubmed: 30479379
doi: 10.1038/s41577-018-0092-5
pii: 10.1038/s41577-018-0092-5
pmc: PMC6352731
mid: NIHMS1002981
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-62Subventions
Organisme : NIAID NIH HHS
ID : R01 AI048935
Pays : United States
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