Regulation of phagosome functions by post-translational modifications: a new paradigm.
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
06
07
2018
revised:
02
11
2018
accepted:
02
11
2018
pubmed:
28
11
2018
medline:
18
5
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
Phagosomes are highly dynamic organelles formed by the uptake of particles through phagocytic innate immune cells such as macrophages. Their key roles in microbe elimination and antigen presentation make them essential for innate and adaptive immunity. However, phagosomes are also important for tissue homeostasis as even in healthy individuals billions of dead cells are phagocytosed each day. In this short review, we highlight how the use of latex beads as inert baits for phagocytosis and subsequent analysis by proteomics has changed our understanding of the phagosome. We further discuss recent data on post-translational modifications such as phosphorylation and ubiquitylation that regulate phagosome functions and demonstrate that the phagosome is not only a 'degradative organelle' but also serves as a subcellular signalling platform.
Identifiants
pubmed: 30481638
pii: S1367-5931(18)30084-X
doi: 10.1016/j.cbpa.2018.11.001
pii:
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-80Subventions
Organisme : Medical Research Council
ID : MC_UU_12016/5
Pays : United Kingdom
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.