Cerebrovascular reactivity to hypercapnia during sevoflurane or desflurane anesthesia in rats.
Anesthetics, Inhalation
/ adverse effects
Animals
Arterioles
/ drug effects
Blood Gas Analysis
Cerebral Veins
/ drug effects
Cerebrovascular Circulation
/ drug effects
Desflurane
/ adverse effects
Hemodynamics
/ drug effects
Hypercapnia
/ physiopathology
Male
Rats
Rats, Sprague-Dawley
Sevoflurane
/ adverse effects
Vasodilation
/ drug effects
Venules
/ drug effects
Cerebrovascular circulation
Desflurane
Hypercapnia
Sevoflurane
Journal
Korean journal of anesthesiology
ISSN: 2005-7563
Titre abrégé: Korean J Anesthesiol
Pays: Korea (South)
ID NLM: 101502451
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
21
08
2018
accepted:
26
11
2018
pubmed:
28
11
2018
medline:
9
4
2020
entrez:
28
11
2018
Statut:
ppublish
Résumé
Hypercapnia causes dilation of cerebral vessels and increases cerebral blood flow, resulting in increased intracranial pressure. Sevoflurane is reported to preserve cerebrovascular carbon dioxide reactivity. However, the contribution of inhaled anesthetics to vasodilatory responses to hypercapnia has not been clarified. Moreover, the cerebrovascular response to desflurane under hypercapnia has not been reported. We examined the effects of sevoflurane and desflurane on vasodilatory responses to hypercapnia in rats. A closed cranial window preparation was used to measure the changes in pial vessel diameters. To evaluate the cerebrovascular response to hypercapnia and/or inhaled anesthetics, the pial vessel diameters were measured in the following states: without inhaled anesthetics at normocapnia (control values) and hypercapnia, with inhaled end-tidal minimal alveolar concentration (MAC) of 0.5 or 1.0 of either sevoflurane or desflurane at normocapnia, and an MAC of 1.0 of sevoflurane or desflurane at hypercapnia. Under normocapnia, 1.0 MAC, but not 0.5 MAC, of sevoflurane or desflurane dilated the pial arterioles and venules. In addition, under both 1.0 MAC of sevoflurane and 1.0 MAC of desflurane, hypercapnia significantly dilated the pial arterioles and venules in comparison to their diameters without inhaled anesthetics. The degrees of vasodilation were similar for desflurane and sevoflurane under both normocapnia and hypercapnia. Desflurane induces cerebrovascular responses similar to those of sevoflurane. Desflurane can be used as safely as sevoflurane in neurosurgical anesthesia.
Sections du résumé
BACKGROUND
BACKGROUND
Hypercapnia causes dilation of cerebral vessels and increases cerebral blood flow, resulting in increased intracranial pressure. Sevoflurane is reported to preserve cerebrovascular carbon dioxide reactivity. However, the contribution of inhaled anesthetics to vasodilatory responses to hypercapnia has not been clarified. Moreover, the cerebrovascular response to desflurane under hypercapnia has not been reported. We examined the effects of sevoflurane and desflurane on vasodilatory responses to hypercapnia in rats.
METHODS
METHODS
A closed cranial window preparation was used to measure the changes in pial vessel diameters. To evaluate the cerebrovascular response to hypercapnia and/or inhaled anesthetics, the pial vessel diameters were measured in the following states: without inhaled anesthetics at normocapnia (control values) and hypercapnia, with inhaled end-tidal minimal alveolar concentration (MAC) of 0.5 or 1.0 of either sevoflurane or desflurane at normocapnia, and an MAC of 1.0 of sevoflurane or desflurane at hypercapnia.
RESULTS
RESULTS
Under normocapnia, 1.0 MAC, but not 0.5 MAC, of sevoflurane or desflurane dilated the pial arterioles and venules. In addition, under both 1.0 MAC of sevoflurane and 1.0 MAC of desflurane, hypercapnia significantly dilated the pial arterioles and venules in comparison to their diameters without inhaled anesthetics. The degrees of vasodilation were similar for desflurane and sevoflurane under both normocapnia and hypercapnia.
CONCLUSIONS
CONCLUSIONS
Desflurane induces cerebrovascular responses similar to those of sevoflurane. Desflurane can be used as safely as sevoflurane in neurosurgical anesthesia.
Identifiants
pubmed: 30481950
pii: kja.d.18.00244
doi: 10.4097/kja.d.18.00244
pmc: PMC6547227
doi:
Substances chimiques
Anesthetics, Inhalation
0
Sevoflurane
38LVP0K73A
Desflurane
CRS35BZ94Q
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-264Commentaires et corrections
Type : CommentIn
Références
Anesthesiology. 1999 Sep;91(3):677-80
pubmed: 10485778
Anesth Analg. 1999 Dec;89(6):1437-41
pubmed: 10589623
Anesthesiology. 1999 Dec;91(6):1720-3
pubmed: 10598615
Br J Anaesth. 2002 Mar;88(3):357-61
pubmed: 11990266
Can J Anaesth. 2003 Feb;50(2):166-71
pubmed: 12560309
Paediatr Anaesth. 2003 Jul;13(6):496-500
pubmed: 12846705
Acta Anaesthesiol Scand. 2003 Sep;47(8):932-8
pubmed: 12904183
Anesth Analg. 1992 Dec;75(6):1000-6
pubmed: 1443679
Acta Neurochir Suppl. 2006;96:435-7
pubmed: 16671500
J Anesth. 2008;22(2):135-9
pubmed: 18500610
Anesth Analg. 2009 Aug;109(2):387-93
pubmed: 19608808
Anesth Analg. 2009 Aug;109(2):567-71
pubmed: 19608833
Anesthesiology. 1989 Jul;71(1):80-6
pubmed: 2751144
Anesth Analg. 1987 Oct;66(10):974-6
pubmed: 3631594
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):392-402
pubmed: 4209160
Anesthesiology. 1998 May;88(5):1365-86
pubmed: 9605698
Anesthesiology. 1998 Oct;89(4):954-60
pubmed: 9778013
Br J Anaesth. 1998 Aug;81(2):155-60
pubmed: 9813515
Anesthesiology. 1998 Dec;89(6):1480-8
pubmed: 9856723