Platinum-loaded mesoporous nickel phosphonate and its electrochemical application for sarcosine detection.
Mesoporous
Nickel phosphonate
Platinum
Prostate cancer
Sarcosine biosensor
Journal
Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
30
07
2018
revised:
02
09
2018
accepted:
13
09
2018
entrez:
29
11
2018
pubmed:
30
11
2018
medline:
28
3
2019
Statut:
ppublish
Résumé
In 2009, Sreekumar found that sarcosine, as an effective biomarker, can be used to identify prostate cancer. However, it is difficult to detect sarcosine in urine or plasma because of its low concentration. In this work, we describe a simple strategy for the preparation of sarcosine biosensor based on platinum-loaded mesoporous nickel phosphonate (Pt/MNP) and subsequently apply it to detect sarcosine. Mesoporous structure could increase the active sites on the MNP surface, which makes the Pt/MNP have excellent electrochemical performance for detecting hydrogen peroxide, one of the enzymatic products, and the sarcosine biosensor exhibited a superior electrochemical performance. The linear range of sarcosine biosensor is from 5 to 40 μM and the sensitivity is 123.51 μA mM
Identifiants
pubmed: 30482306
pii: S0003-2670(18)31098-5
doi: 10.1016/j.aca.2018.09.027
pii:
doi:
Substances chimiques
Organophosphonates
0
Platinum
49DFR088MY
Nickel
7OV03QG267
Sarcosine
Z711V88R5F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-98Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.