The Gold Nanocluster Protects Neurons Directly or via Inhibiting Cytotoxic Secretions of Microglia Cell.

Gold / pharmacology Humans Inflammation Lipopolysaccharides Metal Nanoparticles Microglia NF-kappa B Neurons Neuroprotective Agents

Journal

Journal of nanoscience and nanotechnology
ISSN: 1533-4880
Titre abrégé: J Nanosci Nanotechnol
Pays: United States
ID NLM: 101088195

Informations de publication

Date de publication:
01 04 2019
Historique:
entrez: 30 11 2018
pubmed: 30 11 2018
medline: 1 6 2021
Statut: ppublish

Résumé

Neurodegenerative diseases have become a huge challenge to public health, such as Alzheimer's and Parkinson's diseases. Microglia driving inflammation in the central nervous system (CNS) has been involved in the pathological process of these disorders and could be novel therapy target. However, traditional anti-inflammatory drugs are not effective in alleviating neuroinflammation. In this study, a potential neuroprotective effect of a peptide-templated gold nanocluster (Au

Identifiants

DOI: 10.1166/jnn.2019.15762 PMID: 30486939
pubmed: 30486939
doi: 10.1166/jnn.2019.15762
doi:

Substances chimiques

Lipopolysaccharides 0
NF-kappa B 0
Neuroprotective Agents 0
Gold 7440-57-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1986-1995

Auteurs

Qing Yuan (Q)

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Yawen Yao (Y)

Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.

Xiangchun Zhang (X)

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Jinling Yuan (J)

Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.

Baoyun Sun (B)

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Xueyun Gao (X)

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Cellules › Névroglie › Microglie › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Cellules › Neurones › The Gold Nanocluster Protects Neurons Directly...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › The Gold Nanocluster Protects Neurons Directly...