Microbial impact on cholesterol and bile acid metabolism: current status and future prospects.
cholesterol metabolism
gut microbiota
hypercholesterolemia
metabolic diseases
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
02
08
2018
revised:
25
11
2018
pubmed:
30
11
2018
medline:
13
2
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Recently, the gut microbiota has emerged as a crucial factor that influences cholesterol metabolism. Ever since, significant interest has been shown in investigating these host-microbiome interactions to uncover microbiome-mediated functions on cholesterol and bile acid (BA) metabolism. Indeed, changes in gut microbiota composition and, hence, its derived metabolites have been previously reported to subsequently impact the metabolic processes and have been linked to several diseases. In this context, associations between a disrupted gut microbiome, impaired BA metabolism, and cholesterol dysregulation have been highlighted. Extensive advances in metagenomic and metabolomic studies in this field have allowed us to further our understanding of the role of intestinal bacteria in metabolic health and disease. However, only a few have provided mechanistic insights into their impact on cholesterol metabolism. Identifying the myriad functions and interactions of these bacteria to maintain cholesterol homeostasis remain an important challenge in such a field of research. In this review, we discuss the impact of gut microbiota on cholesterol metabolism, its association with disease settings, and the potential of modulating gut microbiota as a promising therapeutic target to lower hypercholesterolemia.
Identifiants
pubmed: 30487175
pii: S0022-2275(20)32644-4
doi: 10.1194/jlr.R088989
pmc: PMC6358303
doi:
Substances chimiques
Bile Acids and Salts
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
323-332Informations de copyright
Copyright © 2019 Kriaa et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.
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