Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Blood Glucose / metabolism Diabetes Mellitus, Type 2 / genetics Diabetic Retinopathy Genetic Predisposition to Disease Genome-Wide Association Study / methods Genotype Glycated Hemoglobin / metabolism Humans Meta-Analysis as Topic Polymorphism, Single Nucleotide / genetics Protein Binding

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
02 2019
Historique:
received: 23 05 2018
accepted: 12 11 2018
pubmed: 30 11 2018
medline: 6 8 2019
entrez: 30 11 2018
Statut: ppublish

Résumé

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (

Identifiants

DOI: 10.2337/db18-0567 PMID: 30487263 PMC: PMC6341299
pubmed: 30487263
pii: db18-0567
doi: 10.2337/db18-0567
pmc: PMC6341299
doi:

Substances chimiques

Blood Glucose 0
Glycated Hemoglobin A 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

441-456

Subventions

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Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2018 by the American Diabetes Association.

Références

Mediators Inflamm. 2013;2013:748435
pubmed: 23864767
Nat Genet. 2008 May;40(5):638-45
pubmed: 18372903
PLoS Genet. 2012;8(11):e1003032
pubmed: 23144628
Mol Vis. 2012;18:2749-57
pubmed: 23213275
Hum Mol Genet. 2013 Aug 1;22(15):3165-73
pubmed: 23562823
Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3839-45
pubmed: 18765632
Hum Genet. 2015 Feb;134(2):247-57
pubmed: 25487307
Ophthalmology. 1991 May;98(5 Suppl):786-806
pubmed: 2062513
Nature. 2012 Apr 04;485(7397):242-5
pubmed: 22495311
Nat Rev Genet. 2013 Jun;14(6):379-89
pubmed: 23657481
Clin Exp Ophthalmol. 2014 Jul;42(5):486-93
pubmed: 24112246
Diabetologia. 2015 Oct;58(10):2288-97
pubmed: 26188370
Diabetologia. 2015 Jun;58(6):1231-8
pubmed: 25819896
PLoS One. 2015 Sep 09;10(9):e0137358
pubmed: 26352837
PLoS Med. 2017 Sep 12;14(9):e1002383
pubmed: 28898252
Am J Hum Genet. 2016 Jul 7;99(1):76-88
pubmed: 27321947
Diabetologia. 2012 Mar;55(3):671-80
pubmed: 22134840
Ophthalmology. 2012 May;119(5):1041-6
pubmed: 22330960
Hum Mol Genet. 2011 Jun 15;20(12):2472-81
pubmed: 21441570
Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
pubmed: 22064851
Br J Ophthalmol. 2004 Sep;88(9):1137-41
pubmed: 15317703
Acta Ophthalmol. 2018 Nov;96(7):e811-e819
pubmed: 30178632
Biochem Biophys Res Commun. 2012 Jan 20;417(3):1086-92
pubmed: 22226966
Am J Ophthalmol. 2015 Jun;159(6):1152-1160.e2
pubmed: 25794792
J Ophthalmol. 2010;2010:
pubmed: 20871662
Nat Methods. 2014 Aug;11(8):868-74
pubmed: 24952909
Nat Genet. 2018 Sep;50(9):1335-1341
pubmed: 30104761
J Hum Genet. 2016 Oct;61(10):861-866
pubmed: 27305981
Arch Ophthalmol. 1984 Apr;102(4):527-32
pubmed: 6367725
Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5518-5524
pubmed: 27768789
Ophthalmology. 1998 Mar;105(3):406-11
pubmed: 9499768
Ophthalmology. 2012 Apr;119(4):789-801
pubmed: 22330964
PLoS Genet. 2011 Jan 13;7(1):e1001273
pubmed: 21249183
Br J Ophthalmol. 2002 Jan;86(1):84-90
pubmed: 11801510
Hum Genet. 2016 Feb;135(2):193-200
pubmed: 26693933
J Nutrigenet Nutrigenomics. 2016;9(5-6):254-264
pubmed: 28002826
Ophthalmology. 2002 Jul;109(7):1225-34
pubmed: 12093643
Diabetes Care. 2003 Jan;26 Suppl 1:S5-20
pubmed: 12502614
Diabetes. 2015 Apr;64(4):1470-83
pubmed: 25368101
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Am J Ophthalmol. 2009 Mar;147(3):501-4
pubmed: 19054495
Ophthalmology. 2017 Mar;124(3):336-342
pubmed: 28038984
PLoS One. 2014 Nov 03;9(11):e111715
pubmed: 25364816
Am J Ophthalmol. 2006 Mar;141(3):446-455
pubmed: 16490489
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2377-81
pubmed: 22427569
Diabetes. 2007 Apr;56(4):1160-6
pubmed: 17395753
Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7593-602
pubmed: 21873659
Ophthalmology. 2011 Apr;118(4):642-8
pubmed: 21310492

Auteurs

Samuela Pollack (S)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

Robert P Igo (RP)

Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.

Richard A Jensen (RA)

Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.

Mark Christiansen (M)

Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA.

Xiaohui Li (X)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Ching-Yu Cheng (CY)

Duke-NUS Medical School, Singapore.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
ORCID: 0000-0003-0655-885X

Maggie C Y Ng (MCY)

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.

Albert V Smith (AV)

Department of Medicine, University of Iceland, Reykjavík, Iceland.

Elizabeth J Rossin (EJ)

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.

Ayellet V Segrè (AV)

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.

Samaneh Davoudi (S)

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.

Gavin S Tan (GS)

Duke-NUS Medical School, Singapore.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Yii-Der Ida Chen (YI)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Jane Z Kuo (JZ)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.
Medical Affairs, Ophthalmology, Sun Pharmaceutical Industries, Inc., Princeton, NJ.

Latchezar M Dimitrov (LM)

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.

Lynn K Stanwyck (LK)

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA.

Weihua Meng (W)

Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee School of Medicine, Scotland, U.K.

S Mohsen Hosseini (SM)

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Minako Imamura (M)

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.

Darryl Nousome (D)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Jihye Kim (J)

Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.

Yang Hai (Y)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Yucheng Jia (Y)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Jeeyun Ahn (J)

Department of Ophthalmology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Aaron Leong (A)

Endocrine Unit and Diabetes Unit, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA.

Kaanan Shah (K)

Section of Genetic Medicine, University of Chicago, Chicago, IL.

Kyu Hyung Park (KH)

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Xiuqing Guo (X)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Eli Ipp (E)

Section of Diabetes and Metabolism, Harbor-UCLA Medical Center, University of California, Los Angeles, Los Angeles, CA.
ORCID: 0000-0003-1588-0146

Kent D Taylor (KD)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Sharon G Adler (SG)

Department of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-University of California, Torrance, CA.

John R Sedor (JR)

Department of Medicine, Case Western Reserve University, Cleveland, OH.
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.
Division of Nephrology, MetroHealth System, Cleveland, OH.

Barry I Freedman (BI)

Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
ORCID: 0000-0003-0275-5530

I-Te Lee (IT)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
ORCID: 0000-0003-2665-3635

Wayne H-H Sheu (WH)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
School of Medicine, National Defense Medical Center, Taipei, Taiwan.

Michiaki Kubo (M)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Atsushi Takahashi (A)

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan.

Samy Hadjadj (S)

CHU de Poitiers, Centre d'Investigation Clinique, Poitiers, France.
Université de Poitiers, UFR Médecine Pharmacie, Centre d'Investigation Clinique 1402, Poitiers, France.
INSERM, Centre d'Investigation Clinique 1402, Poitiers, France.
L'Institut du Thorax, INSERM, CNRS, CHU Nantes, Nantes, France.
ORCID: 0000-0001-7110-6994

Michel Marre (M)

Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Department of Diabetology, Endocrinology and Nutrition, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Paris, France.
INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.

David-Alexandre Tregouet (DA)

Team Genomics & Pathophysiology of Cardiovascular Diseases, UPMC, Sorbonne Universités, INSERM, UMR_S 1166, Paris, France.
Institute of Cardiometabolism and Nutrition, Paris, France.

Roberta Mckean-Cowdin (R)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Rohit Varma (R)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Mark I McCarthy (MI)

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, U.K.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.
NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K.

Leif Groop (L)

Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.

Emma Ahlqvist (E)

Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.

Valeriya Lyssenko (V)

Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway.

Elisabet Agardh (E)

Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.

Andrew Morris (A)

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.

Alex S F Doney (ASF)

Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.

Helen M Colhoun (HM)

Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, U.K.
ORCID: 0000-0002-8345-3288

Iiro Toppila (I)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Niina Sandholm (N)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-4322-6942

Per-Henrik Groop (PH)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
ORCID: 0000-0003-4055-6954

Shiro Maeda (S)

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.
ORCID: 0000-0001-6688-9875

Craig L Hanis (CL)

Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
ORCID: 0000-0002-4880-5348

Alan Penman (A)

Department of Preventive Medicine, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS.

Ching J Chen (CJ)

Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.

Heather Hancock (H)

Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS.

Paul Mitchell (P)

Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.

Jamie E Craig (JE)

Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia.

Emily Y Chew (EY)

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.

Andrew D Paterson (AD)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Epidemiology and Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-9169-118X

Michael A Grassi (MA)

Grassi Retina, Naperville, IL.
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.

Colin Palmer (C)

Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.

Donald W Bowden (DW)

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.

Brian L Yaspan (BL)

Genentech, Inc., South San Francisco, CA.

David Siscovick (D)

Institute for Urban Health, New York Academy of Medicine, New York, NY.

Mary Frances Cotch (MF)

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD.

Jie Jin Wang (JJ)

Duke-NUS Medical School, Singapore.
Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.

Kathryn P Burdon (KP)

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Tien Y Wong (TY)

Duke-NUS Medical School, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Barbara E K Klein (BEK)

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.
ORCID: 0000-0003-2379-976X

Ronald Klein (R)

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI.
ORCID: 0000-0002-4428-6237

Jerome I Rotter (JI)

Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.

Sudha K Iyengar (SK)

Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH.

Alkes L Price (AL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

Lucia Sobrin (L)

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA lucia_sobrin@meei.harvard.edu.
ORCID: 0000-0003-1575-0819

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questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Multiethnic Genome-Wide Association Study of...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Multiethnic Genome-Wide Association Study of...
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questionsmedicales.fr › Phénomènes génétiques › Génotype › Multiethnic Genome-Wide Association Study of...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Protéines glyquées › Protéine glycosylée sérique › Hémoglobine glycosylée › Multiethnic Genome-Wide Association Study of...
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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méta-analyse comme sujet › Multiethnic Genome-Wide Association Study of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Multiethnic Genome-Wide Association Study of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Multiethnic Genome-Wide Association Study of...