Hepatitis C Virus Escape Studies of Human Antibody AR3A Reveal a High Barrier to Resistance and Novel Insights on Viral Antibody Evasion Mechanisms.
HVR1
antibody escape
hepatitis C virus
immune evasion
liver disease
vaccine
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
26
10
2018
accepted:
20
11
2018
pubmed:
30
11
2018
medline:
18
12
2019
entrez:
30
11
2018
Statut:
epublish
Résumé
Yearly, ∼2 million people become hepatitis C virus (HCV) infected, resulting in an elevated lifetime risk for severe liver-related chronic illnesses. Characterizing epitopes of broadly neutralizing antibodies (NAbs), such as AR3A, is critical to guide vaccine development. Previously identified alanine substitutions that can reduce AR3A binding to expressed H77 envelope were introduced into chimeric cell culture-infectious HCV recombinants (HCVcc) H77(core-NS2)/JFH1. Substitutions G523A, G530A, and D535A greatly reduced fitness, and S424A, P525A, and N540A, although viable, conferred only low-level AR3A resistance. Using highly NAb-sensitive hypervariable region 1 (HVR1)-deleted HCVcc, H77/JFH1
Identifiants
pubmed: 30487284
pii: JVI.01909-18
doi: 10.1128/JVI.01909-18
pmc: PMC6364003
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Epitopes
0
Viral Envelope Proteins
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI100663
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106005
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI079031
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123365
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI106005
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI123861
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
J Hepatol. 2002 Nov;37(5):684-95
pubmed: 12399239
Hepatology. 2013 Nov;58(5):1587-97
pubmed: 23729237
J Virol. 2005 May;79(10):6023-34
pubmed: 15857988
Sci Transl Med. 2014 Sep 17;6(254):254ra129
pubmed: 25232181
Virology. 2012 Jan 20;422(2):174-84
pubmed: 22078164
J Biol Chem. 2006 Jul 7;281(27):18285-95
pubmed: 16675450
J Virol. 2005 Jul;79(13):8217-29
pubmed: 15956567
Hepatology. 2014 Jun;59(6):2140-51
pubmed: 24425349
J Virol. 2010 May;84(10):5277-93
pubmed: 20200247
J Virol. 2005 Sep;79(17):11095-104
pubmed: 16103160
Arch Virol. 1998;143(12):2493-503
pubmed: 9930205
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6205-10
pubmed: 22492964
Clin Infect Dis. 2017 Jan 1;64(1):44-52
pubmed: 27737953
J Mol Biol. 2013 Jun 12;425(11):1899-1914
pubmed: 23458406
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6025-30
pubmed: 17392433
PLoS Pathog. 2017 Dec 18;13(12):e1006735
pubmed: 29253863
Hepatology. 2017 Apr;65(4):1117-1131
pubmed: 27997681
J Virol. 2018 Apr 13;92(9):
pubmed: 29467319
Hepatology. 2016 Dec;64(6):1881-1892
pubmed: 27351277
PLoS Pathog. 2017 Feb 24;13(2):e1006235
pubmed: 28235087
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):997-1002
pubmed: 18195353
EMBO J. 2002 Oct 1;21(19):5017-25
pubmed: 12356718
Biochim Biophys Acta. 2016 Aug;1860(8):1764-75
pubmed: 26278021
Sci Rep. 2015 Aug 04;5:12501
pubmed: 26238798
Hepatology. 2014 Jan;59(1):318-27
pubmed: 24115039
J Virol. 2017 Sep 27;91(20):
pubmed: 28794021
J Virol. 2015 Aug;89(15):7758-75
pubmed: 25995244
Gut. 2015 Nov;64(11):1824-33
pubmed: 26449729
Curr Opin Virol. 2017 Apr;23:113-119
pubmed: 28550816
J Infect Dis. 2019 Jan 1;219(1):68-79
pubmed: 30102355
Gastroenterology. 2007 Feb;132(2):667-78
pubmed: 17258731
Gastroenterology. 2007 Nov;133(5):1614-26
pubmed: 17983807
Hepatology. 2011 Mar;53(3):755-62
pubmed: 21319203
J Virol. 1994 Jun;68(6):3965-70
pubmed: 7514682
J Virol. 2011 Jan;85(1):596-605
pubmed: 20962076
Am J Transplant. 2013 Apr;13(4):1047-1054
pubmed: 23356386
Annu Rev Immunol. 2016 May 20;34:635-59
pubmed: 27168247
PLoS Pathog. 2014 Aug 14;10(8):e1004297
pubmed: 25122476
J Virol. 2015 Dec;89(24):12245-61
pubmed: 26378182
Nat Med. 2008 Jan;14(1):25-7
pubmed: 18064037
J Virol. 2011 Mar;85(5):2224-34
pubmed: 21123377
Virus Res. 2018 Mar 15;248:53-62
pubmed: 29477639
Gut. 2016 Dec;65(12):1988-1997
pubmed: 26589670
Hepatology. 2014 Nov;60(5):1551-62
pubmed: 25043937
Science. 2005 Jul 22;309(5734):623-6
pubmed: 15947137
Hepatology. 2008 Jun;47(6):1846-55
pubmed: 18452146
Curr Infect Dis Rep. 2007 Mar;9(2):94-101
pubmed: 17324345
J Virol. 2006 Aug;80(16):7844-53
pubmed: 16873241
J Virol. 2011 Jul;85(14):7005-19
pubmed: 21543495
J Virol. 2010 Jun;84(11):5751-63
pubmed: 20357091
J Virol. 2011 Oct;85(20):10451-63
pubmed: 21813602
Nat Struct Mol Biol. 2008 Mar;15(3):312-7
pubmed: 18264114
J Hepatol. 2016 Oct;65(1 Suppl):S2-S21
pubmed: 27641985
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19450-5
pubmed: 19052239
J Infect Dis. 2008 Dec 15;198(12):1756-65
pubmed: 19032070
Nature. 2005 Aug 18;436(7053):961-6
pubmed: 16107836
J Clin Invest. 2015 Jan;125(1):437-47
pubmed: 25500884
J Virol. 2011 Mar;85(6):2891-906
pubmed: 21177811
J Hepatol. 2015 Apr;62(1 Suppl):S87-99
pubmed: 25920094
Expert Rev Vaccines. 2016 Dec;15(12):1535-1544
pubmed: 27267297
J Virol. 2015 Sep;89(17):9128-32
pubmed: 26085160
Nat Med. 2005 Jul;11(7):791-6
pubmed: 15951748
J Virol. 2008 Dec;82(24):12020-9
pubmed: 18829747
PLoS One. 2012;7(12):e52651
pubmed: 23300734
J Virol. 2016 Jan 27;90(7):3745-59
pubmed: 26819303
PLoS Pathog. 2012;8(8):e1002895
pubmed: 22952447
PLoS Pathog. 2017 Feb 23;13(2):e1006214
pubmed: 28231271
PLoS Pathog. 2011 Jun;7(6):e1002111
pubmed: 21738473
J Virol. 2006 Sep;80(17):8695-704
pubmed: 16912317
J Virol. 2014 Feb;88(3):1725-39
pubmed: 24257605
J Virol. 2002 Jun;76(11):5326-38
pubmed: 11991961
J Virol. 2008 Jun;82(12):6067-72
pubmed: 18385242
J Virol. 2008 Jan;82(1):184-95
pubmed: 17942554
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13318-23
pubmed: 11078521