Missing Cases of Herpes Simplex Virus (HSV) Infection of the Central Nervous System When the Reller Criteria Are Applied for HSV PCR Testing: a Multicenter Study.
Adolescent
Adult
Aged
Aged, 80 and over
Cerebrospinal Fluid
/ chemistry
Child
Child, Preschool
DNA, Viral
/ genetics
Diagnostic Errors
/ statistics & numerical data
Diagnostic Tests, Routine
/ methods
Encephalitis, Herpes Simplex
/ diagnosis
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Polymerase Chain Reaction
/ methods
Retrospective Studies
Simplexvirus
/ genetics
Young Adult
central nervous system infections
cerebrospinal fluid
herpes simplex virus
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
25
10
2018
accepted:
19
11
2018
pubmed:
30
11
2018
medline:
2
4
2020
entrez:
30
11
2018
Statut:
epublish
Résumé
Previous studies suggested that herpes simplex virus (HSV) PCR testing can be safely deferred in patients with normal cerebrospinal fluid (CSF) white blood cell (WBC) counts and protein levels as long as they are older than 2 years of age and are not immunocompromised, the so-called Reller criteria. In this multicenter study, we retrospectively assessed the validity of these screening criteria in our setting. A total of 4,404 CSF specimens submitted for HSV PCR testing to the respective microbiology laboratories at the participating hospitals between 2012 and 2018 were included. Six commercially available HSV PCR assays were used across the participating centers. Ninety-one of the 4,404 CSF specimens (2.1%) tested were positive for HSV DNA (75 samples for HSV-1 and 16 for HSV-2). Nine patients failed to meet the Reller criteria, of whom seven were deemed to truly have HSV encephalitis. Overall, no significant correlation between HSV PCR cycle threshold (
Identifiants
pubmed: 30487303
pii: JCM.01719-18
doi: 10.1128/JCM.01719-18
pmc: PMC6355537
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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