Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.

Acute Kidney Injury / enzymology Aldehyde Reductase / deficiency Animals Cell Line Coenzyme A / metabolism Female Glycolysis HEK293 Cells Humans Kidney Tubules, Proximal / enzymology Male Metabolic Engineering Mice Mutation Nitric Oxide Synthase Type III / metabolism Oxidation-Reduction Oxidoreductases / metabolism Pentose Phosphate Pathway Protein Multimerization Pyruvate Kinase / antagonists & inhibitors

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
01 2019
Historique:
received: 20 04 2018
accepted: 31 10 2018
pubmed: 30 11 2018
medline: 30 6 2019
entrez: 30 11 2018
Statut: ppublish

Résumé

Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the molecular mechanisms of this protection are poorly understood

Identifiants

DOI: 10.1038/s41586-018-0749-z PMID: 30487609 PMC: PMC6318002
pubmed: 30487609
doi: 10.1038/s41586-018-0749-z
pii: 10.1038/s41586-018-0749-z
pmc: PMC6318002
mid: NIHMS1511348
doi:

Substances chimiques

S-nitroso-coenzyme A 82494-50-6
Oxidoreductases EC 1.-
Akr1a1 protein, mouse EC 1.1.1.2
Aldehyde Reductase EC 1.1.1.21
Nitric Oxide Synthase Type III EC 1.14.13.39
Pyruvate Kinase EC 2.7.1.40
Coenzyme A SAA04E81UX

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

96-100

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL126900
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK095072
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139424
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL109250
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027002
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL128192
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119506
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL075443
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : ErratumIn

Références

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Auteurs

Hua-Lin Zhou (HL)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Rongli Zhang (R)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Puneet Anand (P)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Colin T Stomberski (CT)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Zhaoxia Qian (Z)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Alfred Hausladen (A)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Liwen Wang (L)

Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Eugene P Rhee (EP)

Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Samir M Parikh (SM)

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

S Ananth Karumanchi (SA)

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jonathan S Stamler (JS)

Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA. jonathan.stamler@case.edu.
Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. jonathan.stamler@case.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Aldo-keto reductases › Aldose reductase › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Eucaryotes › Animaux › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Tubules contournés proximaux › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Nitric oxide synthase type III › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voie des pentoses phosphates › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Metabolic reprogramming by the S-nitroso-CoA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Pyruvate kinase › Metabolic reprogramming by the S-nitroso-CoA...