Physical Performance and Vitamin D in Elderly Black Women-The PODA Randomized Clinical Trial.
Black or African American
/ statistics & numerical data
Aged
Case-Control Studies
Cholecalciferol
/ administration & dosage
Dietary Supplements
Double-Blind Method
Female
Follow-Up Studies
Humans
Middle Aged
Osteoporosis
/ blood
Physical Functional Performance
Prognosis
Prospective Studies
Vitamin D Deficiency
/ complications
Vitamins
/ administration & dosage
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
29
06
2018
accepted:
20
11
2018
pubmed:
30
11
2018
medline:
28
2
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
There is limited information on the influence of vitamin D on physical performance in black Americans. To determine if maintenance of serum 25(OH)D >75 nmol/L prevents a decline in physical performance. The Physical Performance, Osteoporosis and Vitamin D in African American Women (PODA) trial had a prospective, randomized, placebo controlled, double-dummy design with two arms: one of which is placebo vitamin D3 adjusted to maintain serum 25(OH)D >75 nmol/L. The target population was healthy elderly black women with serum 25(OH)D between 20 and 65 nmol/L. The trial was 3 years in duration with measurement of physical performance every 6 months: grip strength, Short Physical Performance Battery (SPPB), 10 chair rises, and 6-minute walk distance. A total of 260 women entered the study and 184 completed 3 years. Mean age was 68.2 years. Baseline 25(OH)D was 53 nmol/L; total SPPB was 11 (10 to 12). Research center in an academic health center. Prevention of decline in physical performance measures. Participants were randomly assigned to placebo or active vitamin D. Vitamin D3 dose was adjusted to maintain serum 25(OH)D >75 nmol/L. There was a decline with time in grip strength and the 6-minute walk test. The SPBB increased with time. There were no substantial differences between the placebo and active vitamin D3 groups with respect to the temporal patterns observed for any of the performance measures. There is no benefit of maintaining serum 25(OH)D >75 nmol/L in preventing the decline in physical performance in healthy black American women.
Identifiants
pubmed: 30496578
pii: 5210408
doi: 10.1210/jc.2018-01418
pmc: PMC6435095
doi:
Substances chimiques
Vitamins
0
Cholecalciferol
1C6V77QF41
Banques de données
ClinicalTrials.gov
['NCT01153568']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1441-1448Subventions
Organisme : NIA NIH HHS
ID : R01 AG032440
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
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