As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Cardiac aging
Epigenetics
Fruit fly
Obesity
Proteostasis
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
01
08
2018
revised:
05
11
2018
accepted:
13
11
2018
pubmed:
30
11
2018
medline:
5
3
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
Identifiants
pubmed: 30496794
pii: S0925-4439(18)30469-1
doi: 10.1016/j.bbadis.2018.11.010
pmc: PMC6527462
mid: NIHMS1516621
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1831-1844Subventions
Organisme : British Heart Foundation
ID : FS_13 17_29905
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL054732
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031862
Pays : United States
Organisme : NIA NIH HHS
ID : R13 AG033456
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG033561
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124091
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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