Effects of Intrauterine Air Bubbles on Embryonic Development in Mice.
Journal
Journal of the American Association for Laboratory Animal Science : JAALAS
ISSN: 2769-6677
Titre abrégé: J Am Assoc Lab Anim Sci
Pays: United States
ID NLM: 101269489
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
pubmed:
1
12
2018
medline:
7
2
2020
entrez:
1
12
2018
Statut:
ppublish
Résumé
During murine embryo transfer, air bubbles frequently are loaded with embryos into the transfer catheter, but the role of air bubbles on embryonic development is unclear. This study shows that intrauterine air disrupted embryo spacing, induced deciduoma, and impaired postimplantation development. RNA sequencing showed that the gene expression profile of air-induced deciduoma differed significantly from that of embryo-induced decidua but is similar to tetraploid-induced deciduoma. A subset of 33 common genes was upregulated in the embryo-induced decidua compared with air- or tetraploid-induced deciduoma. These data suggest that the inner cell mass (ICM) plays a key role in regulating decidualization and that the trophectoderm is an intermediate that relays ICM-derived signals to other target cells. Our results may provide an innovative approach for detecting the developmental status of embryos in human reproductive medicine.
Identifiants
pubmed: 30497539
doi: 10.30802/AALAS-JAALAS-18-000031
pmc: PMC6351051
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-15Références
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