Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets.
Fatty acid metabolism
Fatty acid transport protein4
High-sugar diets
Lipolysis
Triglycerides
Journal
Molecular genetics and metabolism
ISSN: 1096-7206
Titre abrégé: Mol Genet Metab
Pays: United States
ID NLM: 9805456
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
07
09
2018
revised:
12
11
2018
accepted:
17
11
2018
pubmed:
1
12
2018
medline:
14
8
2019
entrez:
1
12
2018
Statut:
ppublish
Résumé
Fatty acid transport protein4 (FATP4) is upregulated in acquired and central obesity and its polymorphisms are associated with blood lipids and insulin resistance. Patients with FATP4 mutations and mice with global FATP4 deletion exhibit skin abnormalities characterized as ischthyosis prematurity syndrome (IPS). Cumulating data have shown that an absence of FATP4 increases the levels of cellular triglycerides (TG). However, FATP4 role and consequent lipid and TG metabolism in the hepatocyte is still elusive. Here, hepatocyte-specific FATP4 deficient (Fatp4
Identifiants
pubmed: 30497809
pii: S1096-7192(18)30556-0
doi: 10.1016/j.ymgme.2018.11.010
pii:
doi:
Substances chimiques
Fatty Acid Transport Proteins
0
Fatty Acids
0
Slc27a4 protein, mouse
0
Triglycerides
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
30-38Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.