Role of autonomic nervous system in atrial fibrillation.
Atrial fibrillation
Autonomic nervous system
Hypertension
Renal denervation
Risk factors
Sleep apnea
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
12
07
2018
revised:
01
11
2018
accepted:
14
11
2018
pubmed:
1
12
2018
medline:
17
3
2020
entrez:
1
12
2018
Statut:
ppublish
Résumé
Atrial fibrillation is the most common sustained arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system has a significant role in the milieu predisposing to the triggers, perpetuators and substrate for atrial fibrillation. It has direct electrophysiological effects and causes alterations in atrial structure. In a significant portion of patients with atrial fibrillation, the autonomic nervous system activity is likely a composite of reflex excitation due to atrial fibrillation itself and contribution of concomitant risk factors such as hypertension, obesity and sleep-disordered breathing. We review the role of autonomic nervous system activation, with focus on changes in reflex control during atrial fibrillation and the role of combined sympatho-vagal activation for atrial fibrillation initiation, maintenance and progression. Finally, we discuss the potential impact of combined aggressive risk factor management as a strategy to modify the autonomic nervous system in patients with atrial fibrillation and to reverse the arrhythmogenic substrate.
Identifiants
pubmed: 30497894
pii: S0167-5273(18)31862-X
doi: 10.1016/j.ijcard.2018.11.091
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-188Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.