Non-invasive delivery strategies for biologics.
Journal
Nature reviews. Drug discovery
ISSN: 1474-1784
Titre abrégé: Nat Rev Drug Discov
Pays: England
ID NLM: 101124171
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
1
12
2018
medline:
9
11
2019
entrez:
1
12
2018
Statut:
ppublish
Résumé
Biologics now constitute a significant element of available medical treatments. Owing to their clinical and commercial success, biologics are a rapidly growing class and have become a dominant therapeutic modality. Although most of the successful biologics to date are drugs that bear a peptidic backbone, ranging from small peptides to monoclonal antibodies (~500 residues; 150 kDa), new biologic modalities, such as nucleotide-based therapeutics and viral gene therapies, are rapidly maturing towards widespread clinical use. Given the rise of peptides and proteins in the pharmaceutical landscape, tremendous research and development interest exists in developing less-invasive or non-invasive routes for the systemic delivery of biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes. This Review summarizes the current status, latest updates and future prospects for such delivery of peptides, proteins and other biologics.
Identifiants
pubmed: 30498202
pii: nrd.2018.183
doi: 10.1038/nrd.2018.183
doi:
Substances chimiques
Biological Products
0
Drug Carriers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-40Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097379
Pays : United States
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