The inhibition of glycosaminoglycan incorporation influences the cell proliferation and cytodifferentiation in cultured embryonic mouse molars.
Animals
Cell Differentiation
/ drug effects
Cell Proliferation
/ drug effects
Embryo, Mammalian
Extracellular Matrix
/ chemistry
Glycosaminoglycans
/ antagonists & inhibitors
Hymecromone
/ analogs & derivatives
Mice
Molar
/ cytology
Odontogenesis
/ drug effects
Proteoglycans
/ metabolism
Tooth Germ
/ cytology
Ameloblasts
Cell proliferation
Cytodifferentiation
Glycosaminoglycan
Odontoblasts
Proteoglycans
Journal
Journal of molecular histology
ISSN: 1567-2387
Titre abrégé: J Mol Histol
Pays: Netherlands
ID NLM: 101193653
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
15
07
2018
accepted:
08
11
2018
pubmed:
1
12
2018
medline:
5
2
2019
entrez:
1
12
2018
Statut:
ppublish
Résumé
The extracellular matrix (ECM) contains a variety of complex macromolecules including proteoglycans (PGs) and glycosaminoglycans (GAGs). PG consists of a protein core with covalently attached carbohydrate side chains called GAGs. Several PGs, including versican, biglycan, decorin and syndecan are involved in odontogenesis while the role of GAGs in those PGs in this process remains unclarified. The purpose of this study was to investigate the influence of GAGs on tooth development. The mandibular first molars at early bell stage were cultivated with or without 4-methylumbelliferyl-β-D-xyloside (Xyl-MU). The cultured tooth germs were metabolically labelled with [
Identifiants
pubmed: 30498999
doi: 10.1007/s10735-018-9803-2
pii: 10.1007/s10735-018-9803-2
doi:
Substances chimiques
Glycosaminoglycans
0
Proteoglycans
0
Hymecromone
3T5NG4Q468
methylumbelliferyl-beta-D-xyloside
6734-33-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-19Références
Connect Tissue Res. 1999;40(1):37-47
pubmed: 10770649
Matrix Biol. 2001 Sep;20(5-6):367-73
pubmed: 11566271
Calcif Tissue Int. 2001 Jul;69(1):38-45
pubmed: 11685432
J Biol Chem. 2002 May 24;277(21):18397-403
pubmed: 11877400
Curr Opin Cell Biol. 2002 Oct;14(5):617-23
pubmed: 12231358
J Cell Sci. 2003 May 1;116(Pt 9):1647-8
pubmed: 12665545
Braz J Med Biol Res. 2003 Aug;36(8):1061-5
pubmed: 12886460
Connect Tissue Res. 2003;44 Suppl 1:167-70
pubmed: 12952192
Cell. 2003 Sep 19;114(6):727-37
pubmed: 14505572
Arch Oral Biol. 1992 Aug;37(8):623-8
pubmed: 1514935
FASEB J. 2004 Jun;18(9):948-58
pubmed: 15173106
Dev Dyn. 2004 Sep;231(1):98-108
pubmed: 15305290
Curr Opin Neurobiol. 2005 Feb;15(1):116-20
pubmed: 15721753
Differentiation. 1990 Mar;43(1):37-50
pubmed: 1694801
Nature. 2007 Apr 26;446(7139):1030-7
pubmed: 17460664
Trends Neurosci. 2008 Jan;31(1):44-52
pubmed: 18063497
Dev Biol. 2010 May 1;341(1):126-40
pubmed: 19854168
Anat Rec. 1991 Feb;229(2):259-70
pubmed: 2012313
Matrix Biol. 2010 Jun;29(5):411-9
pubmed: 20211728
J Steroid Biochem Mol Biol. 2010 Oct;122(4):159-63
pubmed: 20673848
Arch Oral Biol. 2010 Dec;55(12):995-1006
pubmed: 20813348
Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):608-15
pubmed: 21205989
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17022-7
pubmed: 21969569
J Oral Biosci. 2011;53(1):72-81
pubmed: 22200993
Histochem Cell Biol. 2012 Sep;138(3):461-75
pubmed: 22617995
Semin Cell Dev Biol. 2014 Jan-Feb;25-26:61-70
pubmed: 24355560
Acta Med Iran. 2013;51(11):740-50
pubmed: 24390942
Dev Biol. 1989 Jun;133(2):515-28
pubmed: 2499495
J Biomech. 2015 Feb 5;48(3):432-40
pubmed: 25560274
J Cell Biol. 1989 Jun;108(6):2495-505
pubmed: 2661564
J Mol Histol. 2017 Dec;48(5-6):337-345
pubmed: 28756608
J Mol Histol. 2018 Oct;49(5):545-553
pubmed: 30099666
Dev Biol. 1988 Oct;129(2):565-72
pubmed: 3417053
J Biol Chem. 1977 Sep 25;252(18):6316-21
pubmed: 561070
J Biol Buccale. 1983 Sep;11(3):173-93
pubmed: 6361015
J Cell Biol. 1983 May;96(5):1443-50
pubmed: 6841454
Int J Dev Biol. 1995 Feb;39(1):51-68
pubmed: 7626422
Development. 1995 Aug;121(8):2303-12
pubmed: 7671797
J Cell Sci. 1993 Jun;105 ( Pt 2):501-11
pubmed: 7691842
Curr Opin Cell Biol. 1996 Dec;8(6):844-50
pubmed: 8939666
J Dent Res. 1997 Nov;76(11):1730-6
pubmed: 9372789
J Biol Chem. 1998 Aug 21;273(34):21439-42
pubmed: 9705269