Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones.
Chondrogenesis
Fgfr1
Frontal bone
Neural crest cell
Osteogenesis
Journal
Medical molecular morphology
ISSN: 1860-1499
Titre abrégé: Med Mol Morphol
Pays: Japan
ID NLM: 101239023
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
28
09
2018
accepted:
21
11
2018
pubmed:
1
12
2018
medline:
17
1
2020
entrez:
1
12
2018
Statut:
ppublish
Résumé
Most facial bones, including frontal bones, are derived from neural crest cells through intramembranous ossification. Fibroblast growth factor receptor 1 (Fgfr1) plays a pivotal role in craniofacial bone development, and loss of Fgfr1 leads to cleft palate and facial cleft defects in newborn mice. However, the potential role of the Fgfr1 gene in neural crest cell-mediated craniofacial development remains unclear. To investigate the role of Fgfr1 in neural crest cells, we analyzed Wnt1-Cre;Fgfr1
Identifiants
pubmed: 30499042
doi: 10.1007/s00795-018-0213-z
pii: 10.1007/s00795-018-0213-z
doi:
Substances chimiques
Fgfr1 protein, mouse
EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
156-163Subventions
Organisme : Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science
ID : Basic Research C Number 24300182
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