Characterization and gonadal hormone regulation of a sexually dimorphic corticotropin-releasing factor receptor 1 cell group.
RRID: AB_2155786
RRID: AB_2296529
RRID: AB_2561044
RRID: AB_300798
RRID: AB_390204
RRID: AB_631470
anteroventral periventricular nucleus
corticotropin-releasing factor receptor 1
estrogen receptor alpha
glucocorticoid receptor
gonadal hormones
sexual differentiation
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
15
08
2018
revised:
16
10
2018
accepted:
09
11
2018
pubmed:
1
12
2018
medline:
18
8
2020
entrez:
1
12
2018
Statut:
ppublish
Résumé
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. Using a validated CRFR1-green fluorescent protein (GFP) reporter mouse, our laboratory recently discovered a nucleus of CRFR1 expressing cells that is prominent in the female rostral anteroventral periventricular nucleus (AVPV/PeN), but largely absent in males. This sex difference is present in the early postnatal period and remains dimorphic into adulthood. The present investigation sought to characterize the chemical composition and gonadal hormone regulation of these sexually dimorphic CRFR1 cells using immunohistochemical procedures. We report that CRFR1-GFP-ir cells within the female AVPV/PeN are largely distinct from other dimorphic cell populations (kisspeptin, tyrosine hydroxylase). However, CRFR1-GFP-ir cells within the AVPV/PeN highly co-express estrogen receptor alpha as well as glucocorticoid receptor. A single injection of testosterone propionate or estradiol benzoate on the day of birth completely eliminates the AVPV/PeN sex difference, whereas adult gonadectomy has no effect on CRFR1-GFP cell number. These results indicate that the AVPV/PeN CRFR1 is regulated by perinatal but not adult gonadal hormones. Finally, female AVPV/PeN CRFR1-GFP-ir cells are activated following an acute 30-min restraint stress, as assessed by co-localization of CRFR1-GFP cells with phosphorylated (p) CREB. CRFR1-GFP/pCREB cells were largely absent in the male AVPV/PeN. Together, these data indicate a stress and gonadal hormone responsive nucleus that is unique to females and may contribute to sex-specific stress responses.
Identifiants
pubmed: 30499109
doi: 10.1002/cne.24588
pmc: PMC6857540
mid: NIHMS1515294
doi:
Substances chimiques
Gonadal Hormones
0
Receptors, Corticotropin-Releasing Hormone
0
CRF receptor type 1
5CLY6W2H1M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1056-1069Subventions
Organisme : NIMH NIH HHS
ID : R01 MH112768
Pays : United States
Organisme : NIMH NIH HHS
ID : R15 MH118692
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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