Design and synthesis of simplified speciophylline analogues and β-carbolines as active molecules against Plasmodium falciparum.

Antimalarials / chemistry Carbolines / chemistry Cells, Cultured Drug Design Humans Oxindoles / chemistry Plasmodium falciparum / drug effects
antimalarial activity speciophylline spirooxindoles β-carbolines

Journal

Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468

Informations de publication

Date de publication:
02 2019
Historique:
received: 25 07 2018
revised: 03 11 2018
accepted: 06 11 2018
pubmed: 1 12 2018
medline: 7 6 2019
entrez: 1 12 2018
Statut: ppublish

Résumé

A structure-activity relationship study of active molecules against chloroquine-resistant Plasmodium falciparum K1 strain is reported. Structurally simplified analogues of antiplasmodial active alkaloids presented similar levels of activity as their corresponding natural products extracted from Guiera senegalensis and Mitragyna inermis with IC

Identifiants

DOI: 10.1002/ddr.21494 PMID: 30499121
pubmed: 30499121
doi: 10.1002/ddr.21494
doi:

Substances chimiques

Antimalarials 0
Carbolines 0
Oxindoles 0
speciophylline 4697-68-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

133-137

Informations de copyright

© 2018 Wiley Periodicals, Inc.

Auteurs

David Pierrot (D)

Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, France.

Véronique Sinou (V)

Aix Marseille University, UMR MD1, Marseille, France.

Sok-Siya Bun (SS)

CNRS, IRD, IMBE, FAC PHARM, Aix Marseille University, Avignon Université, Marseille, France.

Daniel Parzy (D)

Department of Biology, K-plan, Marseille, France.

Nicolas Taudon (N)

Département des plateformes et recherche technologique, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.

Jean Rodriguez (J)

Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, France.

Evelyne Ollivier (E)

CNRS, IRD, IMBE, FAC PHARM, Aix Marseille University, Avignon Université, Marseille, France.

Damien Bonne (D)

Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, France.
ORCID: 0000-0003-4479-4626

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Design and synthesis of simplified...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Carbolines › Design and synthesis of simplified...
questionsmedicales.fr › Cellules › Cellules cultivées › Design and synthesis of simplified...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design and synthesis of simplified...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design and synthesis of simplified...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indolizine › Indolizidines › Alcaloïdes indoliques › Oxindoles › Design and synthesis of simplified...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Design and synthesis of simplified...