Is high vitamin B12 status a cause of lung cancer?

Adult Aged Case-Control Studies Female Humans Lung Neoplasms / blood Male Mendelian Randomization Analysis Middle Aged Polymorphism, Single Nucleotide Prospective Studies Smoking Vitamin B 12 / blood

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
15 09 2019
Historique:
received: 23 05 2018
revised: 27 09 2018
accepted: 17 10 2018
pubmed: 1 12 2018
medline: 15 2 2020
entrez: 1 12 2018
Statut: ppublish

Résumé

Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case-control study, complemented with a Mendelian randomization (MR) approach in an independent case-control sample. We used pre-diagnostic biomarker data from 5183 case-control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre-diagnostic blood samples from the nested case-control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [OR

Identifiants

DOI: 10.1002/ijc.32033 PMID: 30499135 PMC: PMC6642017
pubmed: 30499135
doi: 10.1002/ijc.32033
pmc: PMC6642017
mid: EMS84323
doi:

Substances chimiques

Vitamin B 12 P6YC3EG204

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1499-1503

Subventions

Organisme : NCI NIH HHS
ID : U19 CA203654
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182934
Pays : United States
Organisme : Cancer Research UK
ID : C18281/A19169
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : UM1 CA182910
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148127
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA155340
Pays : United States
Organisme : Cancer Research UK
ID : A19169
Pays : United Kingdom

Informations de copyright

© 2018 International Agency for Research on Cancer (IARC/WHO); licensed by UICC.

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Auteurs

Anouar Fanidi (A)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

Robert Carreras-Torres (R)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Tricia L Larose (TL)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Jian-Min Yuan (JM)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
ORCID: 0000-0002-4620-3108

Victoria L Stevens (VL)

Epidemiology Research Program, American Cancer Society, Inc., Atlanta, GA.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Ross Prentice (R)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Mary Pettinger (M)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Qiuyin Cai (Q)

Health Promotion Sciences, Division of Epidemiology, Department of Medicine,Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

William J Blot (WJ)

Health Promotion Sciences, Division of Epidemiology, Department of Medicine,Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
International Epidemiology Institute, Rockville, MD.

Alan A Arslan (AA)

Department of Obstetrics and Gynecology, Population Health and Environmental Medicine, New York University School of Medicine, New York, NY.

Anne Zeleniuch-Jacquotte (A)

Department of Population Health, New York University School of Medicine, New York, NY.

Marjorie L McCullough (ML)

Epidemiology Research Program, American Cancer Society, Inc., Atlanta, GA.

Loic Le Marchand (L)

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI.

Lynne R Wilkens (LR)

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI.

Christopher A Haiman (CA)

Keck School of Medicine, University of Southern California, Los Angeles, CA.

Xuehong Zhang (X)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
ORCID: 0000-0002-8260-8508

Meir J Stampfer (MJ)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA.

Stephanie A Smith-Warner (SA)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA.

Edward Giovannucci (E)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA.

Graham G Giles (GG)

Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.

Allison M Hodge (AM)

Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
ORCID: 0000-0001-5464-2197

Gianluca Severi (G)

Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy.
Inserm (Institut National de la Sante et de la Recherche Medicale), Centre for Research in Epidemiology and Population Health, Villejuif, France.

Mikael Johansson (M)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Kjell Grankvist (K)

Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.

Arnulf Langhammer (A)

HUNT Research Centre, Department of Public Health and General Practice, NTNU, Norwegian University of Science and Technology, Levanger, Norway.

Ben M Brumpton (BM)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Renwei Wang (R)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.

Yu-Tang Gao (YT)

Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.

Ulrika Ericson (U)

Diabetes and Cardiovascular disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University Malmö, Lund, Sweden.
Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.

Stig E Bojesen (SE)

Diabetes and Cardiovascular disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University Malmö, Lund, Sweden.

Susanne M Arnold (SM)

UK Markey Cancer Center, University of Kentuky, Lexington, KY.

Woon-Puay Koh (WP)

Duke-NUS Graduate Medical School, Singapore, Singapore.

Xiao-Ou Shu (XO)

Health Promotion Sciences, Division of Epidemiology, Department of Medicine,Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
ORCID: 0000-0002-0711-8314

Yong-Bing Xiang (YB)

Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.
ORCID: 0000-0002-3840-9915

Honglan Li (H)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Wei Zheng (W)

Health Promotion Sciences, Division of Epidemiology, Department of Medicine,Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
ORCID: 0000-0003-1226-070X

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Kala Visvanathan (K)

Department of Epidemiology, George W Comstock Center for Public Health Research and Prevention Health Monitoring Unit, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Judith Hoffman-Bolton (J)

Department of Epidemiology, George W Comstock Center for Public Health Research and Prevention Health Monitoring Unit, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Per M Ueland (PM)

Laboratory of Clinical Biochemistry, Department of Clinical Science, University of Bergen, Bergen, Norway.
Haukeland University Hospital, Bergen, Norway.

Øivind Midttun (Ø)

Bevital AS, Bergen, Norway.

Neil E Caporaso (NE)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Mark Purdue (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
ORCID: 0000-0003-1177-3108

Neal D Freedman (ND)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Julie E Buring (JE)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

I-Min Lee (IM)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Howard D Sesso (HD)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

J Michael Gaziano (J)

Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Boston VA Medical Center, Boston, MA.

Jonas Manjer (J)

Department of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.

Caroline L Relton (CL)

Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.
MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

Rayjean J Hung (RJ)

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.

Chris I Amos (CI)

Department of Biomedical Data Science, Geisel School of medicine, Dartmouth College, Lebanon, PA.

Mattias Johansson (M)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Paul Brennan (P)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
ORCID: 0000-0002-0518-8714

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Is high vitamin B12 status a cause of lung cancer?
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Tétrapyrroles › Corrinoïdes › Vitamine B12 › Is high vitamin B12 status a cause of lung cancer?