A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.

Case-Control Studies Contraceptives, Oral, Hormonal Environment Environmental Exposure / adverse effects Female Gene-Environment Interaction Genetic Predisposition to Disease / genetics Genome-Wide Association Study / methods Genotype Humans Ovarian Neoplasms / etiology Polymorphism, Single Nucleotide / genetics Risk
G × E additive interaction genetics ovarian cancer

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 05 2019
Historique:
received: 15 08 2018
accepted: 24 10 2018
pubmed: 1 12 2018
medline: 9 8 2019
entrez: 1 12 2018
Statut: ppublish

Résumé

As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs. never) and rs13255292 (p value = 3.48 × 10

Identifiants

DOI: 10.1002/ijc.32029 PMID: 30499236 PMC: PMC6399057
pubmed: 30499236
doi: 10.1002/ijc.32029
pmc: PMC6399057
mid: NIHMS1000032
doi:

Substances chimiques

Contraceptives, Oral, Hormonal 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Pagination

2192-2205

Subventions

Organisme : NCI NIH HHS
ID : U01 CA069417
Pays : United States
Organisme : Cancer Research UK
ID : 10124
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA087538
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA080742
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA074850
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA105009
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA080668
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA076016
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA095666
Pays : United States
Organisme : Cancer Research UK
ID : 10119
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : N01 PC067010
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA159981
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000056
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA095023
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA067262
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA113148
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058598
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA138563
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058860
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA063678
Pays : United States
Organisme : CIHR
ID : MOP-86727
Pays : Canada
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA193860
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA083918
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA115195
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054419
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122443
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160669
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES013678
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES020811
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA017054
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN025403
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112523
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA136393
Pays : United States

Informations de copyright

© 2018 UICC.

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Auteurs

Sehee Kim (S)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Miao Wang (M)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Jonathan P Tyrer (JP)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

Allan Jensen (A)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Ashley Wiensch (A)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Gang Liu (G)

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Alice W Lee (AW)

Department of Public Health, California State University, Fullerton, Fullerton, CA, USA.

Roberta B Ness (RB)

University of Texas School of Public Health, Houston, TX, USA.

Maxwell Salvatore (M)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-3659-1514

Shelley S Tworoger (SS)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Alice S Whittemore (AS)

Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.

Hoda Anton-Culver (H)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
ORCID: 0000-0002-9603-0110

Weiva Sieh (W)

Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Sara H Olson (SH)

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Andrew Berchuck (A)

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Ellen L Goode (EL)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-9094-8326

Marc T Goodman (MT)

Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Community and Population Health Research Institute, Los Angeles, CA, USA.

Jennifer Anne Doherty (JA)

Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Mary Anne Rossing (MA)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Graham G Giles (GG)

Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Kathryn L Terry (KL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.

Argyrios Ziogas (A)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.

Renée T Fortner (RT)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-1426-8505

Usha Menon (U)

Gynaecological Cancer Research Centre, Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.

Simon A Gayther (SA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0003-0546-902X

Honglin Song (H)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

Angela Brooks-Wilson (A)

Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Elisa V Bandera (EV)

Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Linda S Cook (LS)

University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, USA.
Division of Cancer Care, Department of Population Health Research, Alberta Health Services, Calgary, AB, Canada.

Daniel W Cramer (DW)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0002-8024-3066

Roger L Milne (RL)

Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Stacey J Winham (SJ)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Susanne K Kjaer (SK)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Francesmary Modugno (F)

Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
ORCID: 0000-0003-0637-1534

Pamela J Thompson (PJ)

Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Holly R Harris (HR)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Joellen M Schildkraut (JM)

Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Nhu D Le (ND)

Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.

Nico Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Britton Trabert (B)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-1539-6090

Estrid Høgdall (E)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

David Huntsman (D)

British Columbia's Ovarian Cancer Research (OVCARE) program, Vancouver General Hospital, BC Cancer and University of British Columbia.
Department of Pathology and Laboratory Medicine, and Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.

Malcolm C Pike (MC)

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
ORCID: 0000-0003-4891-1199

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Celeste Leigh Pearce (CL)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
ORCID: 0000-0002-8023-7846

Bhramar Mukherjee (B)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › A comprehensive gene-environment interaction...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs de la reproduction › Contraceptifs › Contraceptifs hormonaux › Contraceptifs oraux hormonaux › A comprehensive gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Environnement › A comprehensive gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › A comprehensive gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › A comprehensive gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › A comprehensive gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A comprehensive gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Génotype › A comprehensive gene-environment interaction...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A comprehensive gene-environment interaction...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › A comprehensive gene-environment interaction...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A comprehensive gene-environment interaction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › A comprehensive gene-environment interaction...