Designing dual-functionalized carbon nanotubes with high blood-brain-barrier permeability for precise orthotopic glioma therapy.

Animals Antineoplastic Agents / pharmacology Blood-Brain Barrier / drug effects Cell Membrane Permeability / drug effects Cell-Penetrating Peptides / administration & dosage Glioma / drug therapy Humans Mice Nanotubes, Carbon / chemistry Oxaliplatin / pharmacology Tumor Cells, Cultured

Journal

Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026

Informations de publication

Date de publication:
07 Feb 2019
Historique:
pubmed: 1 12 2018
medline: 14 5 2019
entrez: 1 12 2018
Statut: ppublish

Résumé

Herein we designed and synthesized a cell penetrating peptide- and cancer-targeted molecule-functionalized multi-walled carbon nanotube for precise orthotopic glioma therapy. In addition to reduced toxicity, this nanosystem exhibited enhanced cancer recognition, blood-brain barrier (BBB) penetration, and anticancer activity through increased ROS production.

Identifiants

DOI: 10.1039/c8dt03948h PMID: 30499579
pubmed: 30499579
doi: 10.1039/c8dt03948h
doi:

Substances chimiques

Antineoplastic Agents 0
Cell-Penetrating Peptides 0
Nanotubes, Carbon 0
Oxaliplatin 04ZR38536J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1569-1573

Auteurs

Yuanyuan You (Y)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Ni Wang (N)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Lizhen He (L)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Changzheng Shi (C)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Dong Zhang (D)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Yiyong Liu (Y)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Liangping Luo (L)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.

Tianfeng Chen (T)

The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn.
ORCID: 0000-0001-6953-1342

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Perméabilité des membranes cellulaires › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides de pénétration cellulaire › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanotubes › Nanotubes de carbone › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Oxaliplatine › Designing dual-functionalized carbon nanotubes...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Designing dual-functionalized carbon nanotubes...