Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.

8,11,14-Eicosatrienoic Acid / analogs & derivatives Analgesics / pharmacology Animals Cerebral Hemorrhage / complications Disease Models, Animal Gabapentin / pharmacology Hyperalgesia / drug therapy Male Pregnanolone / metabolism Proof of Concept Study Random Allocation Rats, Sprague-Dawley Receptors, GABA-A / metabolism Stroke / complications Thalamus
14,15-Epoxyeicosatrienoic acid allopregnanolone central poststroke pain steroidogenic acute regulatory protein δ-subunit-containing gamma-aminobutyric acid receptors

Journal

The journal of pain
ISSN: 1528-8447
Titre abrégé: J Pain
Pays: United States
ID NLM: 100898657

Informations de publication

Date de publication:
05 2019
Historique:
received: 04 06 2018
revised: 05 11 2018
accepted: 13 11 2018
pubmed: 1 12 2018
medline: 20 8 2020
entrez: 1 12 2018
Statut: ppublish

Résumé

Central poststroke pain (CPSP) is a neuropathic pain syndrome arising after a lesion of the central nervous system owing to cerebrovascular insult. Impaired daily activities and reduced quality of life in people suffering from CPSP justify the need for improved treatment. The detailed mechanism of CPSP is not well understood, but central disinhibition has been suggested. Recent reports indicated that epoxyeicosatrienoic acids (EETs), the cytochrome P450 metabolites of arachidonic acid, promoted neuronal survival after stroke, displayed antinociception in peripheral inflammatory pain, and reduced neuronal excitability in seizure model. Here, we tested the hypothesis that 14,15-EET may attenuate CPSP by suppressing thalamic disinhibition through neurosteroids-δ-subunit-containing gamma-aminobutyric acid A receptors (δGABA

Identifiants

DOI: 10.1016/j.jpain.2018.11.006 PMID: 30500366
pubmed: 30500366
pii: S1526-5900(18)30911-8
doi: 10.1016/j.jpain.2018.11.006
pii:
doi:

Substances chimiques

Analgesics 0
Gabrd protein, rat 0
Receptors, GABA-A 0
Gabapentin 6CW7F3G59X
14,15-epoxy-5,8,11-eicosatrienoic acid 81276-03-1
Pregnanolone BXO86P3XXW
8,11,14-Eicosatrienoic Acid FC398RK06S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

577-591

Informations de copyright

Copyright © 2018 the American Pain Society. Published by Elsevier Inc. All rights reserved.

Auteurs

Xuhui Chen (X)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Zuofan Li (Z)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Bo Zhang (B)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Rong Hu (R)

Department of Anaesthesiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Jiayan Li (J)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Miaomiao Feng (M)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Wenlong Yao (W)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Chuanhan Zhang (C)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Li Wan (L)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Yue Zhang (Y)

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address: y.zhang0604@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acide éicosatriénoïque-8,11,14 › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Eucaryotes › Animaux › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie cérébrale › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Gabapentine › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles somatosensoriels › Hyperalgésie › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnanolone › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Étude de validation de principe › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Alleviation of Mechanical Allodynia by...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Thalamus › Alleviation of Mechanical Allodynia by...