The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease.
Journal
Vascular pharmacology
ISSN: 1879-3649
Titre abrégé: Vascul Pharmacol
Pays: United States
ID NLM: 101130615
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
01
06
2018
revised:
22
11
2018
accepted:
22
11
2018
pubmed:
7
12
2018
medline:
10
4
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical modulators of phenotypic changes associated with physiological and pathological contexts in a variety of cardiovascular diseases (CVDs). Although it has been well established that hereditable genetic alterations and exposure to risk factors are crucial in the development of CVDs, other critical regulators of cell function impact on disease processes. Here we discuss noncoding RNAs have only recently been identified as key players involved in the progression of disease. In particular, we discuss micro RNA (miR)-143/145 since they represent one of the most characterised microRNA clusters regulating smooth muscle cell (SMC) differentiation and phenotypic switch in response to vascular injury and remodelling. MiR143HG is a well conserved long noncoding RNA (lncRNA), which is the host gene for miR-143/145 and recently implicated in cardiac specification during heart development. Although the lncRNA-miRNA interactions have not been completely characterised, their crosstalk is now beginning to emerge and likely requires further research focus. In this review we give an overview of the biology of the genomic axis that is miR-143/145 and MiR143HG, focusing on their important functional role(s) in the cardiovascular system.
Identifiants
pubmed: 30502421
pii: S1537-1891(18)30212-X
doi: 10.1016/j.vph.2018.11.006
pmc: PMC6395947
pii:
doi:
Substances chimiques
MIRN143 microRNA, human
0
MIRN145 microRNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-30Subventions
Organisme : British Heart Foundation
ID : FS/18/10/33413
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/14/3/30706
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/12/9/29593
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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