The symptoms at the center: Examining the comorbidity of posttraumatic stress disorder, generalized anxiety disorder, and depression with network analysis.
Depression
GAD
Network analysis
PTSD
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
06
2018
revised:
09
11
2018
accepted:
20
11
2018
pubmed:
5
12
2018
medline:
28
3
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
Comorbid mental health disorders are highly common in trauma-exposed individuals with posttraumatic stress disorder (PTSD), depression, and generalized anxiety disorder (GAD) among the most common co-occurring conditions. Network models of psychopathology offer a novel method to understand how this comorbidity manifests. The present study examined the presence of symptom communities (groups of highly connected symptoms) within a network of these disorders and hub symptoms (symptoms that connect such communities). Cross-sectional data were obtained from a community sample (N = 1184) of trauma exposed adults. Network analyses identified 5 communities: 1 containing all depression and GAD symptoms and 4 for PTSD. The PTSD communities corresponded to symptoms of intrusion and avoidance, hyperarousal, dysphoria, and negative affect. These communities had varying levels of connectivity to the Depression & GAD community. Symptoms of GAD (inability to relax) and PTSD (restricted or diminished positive emotion) were identified as key hub symptoms for the network. The results suggest symptoms of depression and GAD are highly interrelated and that PTSD is heterogeneous. The comorbidity among these diagnoses is thought to stem from their overlap with negative affect.
Identifiants
pubmed: 30502492
pii: S0022-3956(18)30708-8
doi: 10.1016/j.jpsychires.2018.11.016
pmc: PMC6420212
mid: NIHMS1515307
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-58Subventions
Organisme : NIMH NIH HHS
ID : K08 MH107661
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125498
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Biol Psychiatry. 2011 Mar 15;69(6):556-63
pubmed: 21035787
J Abnorm Psychol. 2008 Aug;117(3):662-72
pubmed: 18729617
J Anxiety Disord. 2017 Jan;45:49-59
pubmed: 27936411
Behav Ther. 2012 Sep;43(3):666-78
pubmed: 22697453
Behav Res Methods. 2018 Feb;50(1):195-212
pubmed: 28342071
Psychol Med. 2016 Dec;46(16):3359-3369
pubmed: 27623748
N Engl J Med. 2005 Jun 16;352(24):2515-23
pubmed: 15958807
J Psychopathol Behav Assess. 2018 Jun;40(2):334-343
pubmed: 30270969
J Abnorm Psychol. 2017 Oct;126(7):969-988
pubmed: 29106281
J Affect Disord. 2009 Apr;114(1-3):163-73
pubmed: 18752852
J Trauma Stress. 2018 Aug;31(4):549-557
pubmed: 30025175
J Psychiatr Res. 2015 Sep;68:19-26
pubmed: 26228395
J Psychiatr Res. 2015 Feb;61:106-13
pubmed: 25479765
Arch Intern Med. 2006 May 22;166(10):1092-7
pubmed: 16717171
Psychiatry Res. 2018 Jun;264:76-84
pubmed: 29627700
JAMA Psychiatry. 2017 Feb 1;74(2):135-142
pubmed: 28002832
Annu Rev Clin Psychol. 2009;5:221-47
pubmed: 19327030
Am J Psychiatry. 2010 Mar;167(3):312-20
pubmed: 20048022
Annu Rev Clin Psychol. 2013;9:91-121
pubmed: 23537483
J Affect Disord. 2017 Jan 15;208:490-496
pubmed: 27810269
J Affect Disord. 2015 Apr 1;175:373-8
pubmed: 25665497
Biostatistics. 2008 Jul;9(3):432-41
pubmed: 18079126
J Affect Disord. 2015 Nov 1;186:149-55
pubmed: 26241663
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1118-23
pubmed: 18216267
J Affect Disord. 2018 Mar 15;229:63-68
pubmed: 29306694
Perspect Psychol Sci. 2011 Jan;6(1):3-5
pubmed: 26162106
J Affect Disord. 2015 Mar 15;174:522-6
pubmed: 25556669
J Consult Clin Psychol. 2017 Dec;85(12):1158-1170
pubmed: 29189032
Ann N Y Acad Sci. 1997 Jun 21;821:410-24
pubmed: 9238220