Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives.
Aldehydes
/ chemistry
Amyloid Precursor Protein Secretases
/ antagonists & inhibitors
Binding Sites
Catalytic Domain
Humans
Inhibitory Concentration 50
Ionic Liquids
/ chemistry
Molecular Docking Simulation
Protease Inhibitors
/ chemical synthesis
Pyrans
/ chemical synthesis
Structure-Activity Relationship
1-Butyl-3-imidazolium chloride
Ionic liquid
Molecular docking
Surflex dock
Tetrahydrobenzo [b] pyrans
β-secretase
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
03
2018
revised:
16
11
2018
accepted:
17
11
2018
pubmed:
5
12
2018
medline:
14
1
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
β-Secretase (BACE1) has been broadly documented as one of the possible therapeutic targets for the treatment of Alzheimer's disease. In this paper, we report the synthesis and the for β-secretase (BACE-1) inhibitory activity of new series of tetrahydrobenzo [b] pyran derivatives. One-pot synthesis of tetrahydrobenzo [b] pyrans was carried out by condensing aromatic aldehyde, malononitrile and 1,3-cyclohexanedione using ionic liquid 1-butyl-3-methyl imidazolium chloride ([bmIm]Cl
Identifiants
pubmed: 30502632
pii: S0045-2068(18)30205-0
doi: 10.1016/j.bioorg.2018.11.023
pii:
doi:
Substances chimiques
Aldehydes
0
Ionic Liquids
0
Protease Inhibitors
0
Pyrans
0
Amyloid Precursor Protein Secretases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
202-210Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.