Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?
Autoimmune Diseases
/ immunology
Dermatitis, Atopic
/ immunology
Gastrointestinal Microbiome
/ immunology
Gastrointestinal Tract
/ immunology
Humans
Hypersensitivity
/ immunology
Inflammatory Bowel Diseases
/ immunology
Leukocytes
/ immunology
Mononuclear Phagocyte System
/ immunology
Multiple Sclerosis
/ immunology
Probiotics
Dysbiosis
Gastrointestinal tract
Inflammatory bowel disease
Lactic acid bacteria
Probiotics
Symbiosis
Journal
Maturitas
ISSN: 1873-4111
Titre abrégé: Maturitas
Pays: Ireland
ID NLM: 7807333
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
26
08
2018
revised:
06
11
2018
accepted:
08
11
2018
entrez:
4
12
2018
pubmed:
7
12
2018
medline:
29
1
2019
Statut:
ppublish
Résumé
As a person ages, physiological, immunological and gut microbiome changes collectively result in an array of chronic conditions. According to the 'hygiene hypothesis' the increasing prevalence of immune-mediated disorders may be related to intestinal dysbiosis, leading to immune dysfunction and associated conditions such as eczema, asthma, allergies and autoimmune diseases. Beneficial probiotic bacteria can be utilized by increasing their abundance within the gastrointestinal lumen, which in turn will modulate immune cells, such as, T helper (Th)-1, Th2, Th17, regulatory T (Treg) cells and B cells, which have direct relevance to human health and the pathogenesis of immune disorders. Here, we describe the cross-talk between probiotics and the gastrointestinal immune system, and their effects in relation to inflammatory bowel disease, multiple sclerosis, allergies and atopic dermatitis.
Identifiants
pubmed: 30502748
pii: S0378-5122(18)30552-8
doi: 10.1016/j.maturitas.2018.11.002
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-38Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.