Subcellular Heterogeneity of the microRNA Machinery.
Argonaute
cellular compartments
microRNA
post-transcription
silencing
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
06
08
2018
revised:
20
10
2018
accepted:
26
10
2018
pubmed:
7
12
2018
medline:
20
6
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Different methods have recently been developed to understand the subcellular localization and role of microRNAs (miRNAs) as well as small RNAs associated with Argonaute (AGO) proteins. The heterogeneity of the protein complexes associated with miRNAs, along with their subcellular localization, provides clues into their biochemical mechanism of function. Subcellular diversity indicates that miRNAs localized to different cellular regions could have different functions, including transcriptional regulation on chromatin or post-transcriptional control, providing global regulation of gene expression by miRNAs. Herein, I review the current knowledge and most recent discoveries relating to the subcellular function of miRNAs and other AGO-associated small RNAs, revealing the emergence of a multitude of functions of the miRNA pathway to control different steps of the gene expression program(s).
Identifiants
pubmed: 30503571
pii: S0168-9525(18)30182-3
doi: 10.1016/j.tig.2018.10.006
pii:
doi:
Substances chimiques
Argonaute Proteins
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-28Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.