Mechanical morphogenesis and the development of neocortical organisation.
Arealisation
Development
Evolution
Mechanics
Neocortex
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
04
10
2017
revised:
07
02
2018
accepted:
07
03
2018
pubmed:
7
12
2018
medline:
2
10
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
The development of complex neocortical organisations is thought to result from the interaction of genetic and activity-dependent processes. We propose that a third type of process - mechanical morphogenesis - may also play an important role. We review theoretical and experimental results in physics showing how even homogeneous growth can produce a variety of forms, in particular neocortical folding. The mechanical instabilities that produce these forms induce heterogeneous patterns of stress at the scale of the organ. We review the evidence showing how these stresses can influence cell proliferation, migration and apoptosis, cell differentiation and shape, migration and axonal guidance, and could thus be able to influence regional neocortical identity and connectivity.
Identifiants
pubmed: 30503630
pii: S0010-9452(18)30086-8
doi: 10.1016/j.cortex.2018.03.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-326Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.