State-associated changes in longitudinal [

Adult Age Factors Brain / metabolism Case-Control Studies Cytokines / analysis Fluorine Radioisotopes Gray Matter / metabolism Humans Kynurenine / metabolism Longitudinal Studies Male Microglia / metabolism Middle Aged Neuroimmunomodulation / physiology Positron Emission Tomography Computed Tomography / methods Psychotic Disorders / diagnostic imaging Receptors, GABA / metabolism
Cytokines Kynurenines Microglia Neuroinflammation Positron emission tomography Psychosis Schizophrenia Translocator protein

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
03 2019
Historique:
received: 07 09 2018
revised: 23 11 2018
accepted: 29 11 2018
pubmed: 7 12 2018
medline: 26 2 2020
entrez: 4 12 2018
Statut: ppublish

Résumé

To determine whether state-associated changes in microglial activity, measured with translocator-protein positron emission tomography (TSPO PET), can be identified in psychosis patients through longitudinal evaluation of their regional tracer uptake over the clinical course from acute psychosis to post-treatment follow-up, and comparison to healthy controls. We also evaluated the relation between tracer uptake, clinical symptoms and peripheral immunological markers. Second-generation radioligand [ We found a significant three-way interaction between time of scan, age and cohort (cortical grey matter F6.50, p.020). Age-dependent differences in V We identified a differential age-dependent pattern of TSPO binding from psychosis to follow-up in our cohort of male psychosis patients. We recommend future TSPO PET studies in psychosis patients to differentiate between clinical states and consider potential age-related effects.

Identifiants

DOI: 10.1016/j.bbi.2018.11.318 PMID: 30503836
pubmed: 30503836
pii: S0889-1591(18)30536-1
doi: 10.1016/j.bbi.2018.11.318
pii:
doi:

Substances chimiques

Cytokines 0
Fluorine Radioisotopes 0
Receptors, GABA 0
TSPO protein, human 0
Kynurenine 343-65-7
Fluorine-18 GZ5I74KB8G

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-54

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Livia De Picker (L)

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium. Electronic address: livia.depicker@uantwerp.be.

Julie Ottoy (J)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Steven Deleye (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Leonie Wyffels (L)

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.

Erik Fransen (E)

StatUa Center for Statistics, University of Antwerp, Belgium.

Lauren Kosten (L)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Bernard Sabbe (B)

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium.

Violette Coppens (V)

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium.

Maarten Timmers (M)

Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

Peter de Boer (P)

Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium.

Luc Van Nueten (L)

Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium.

Ken Op De Beeck (K)

Medical Genetics Research Group, University of Antwerp, Antwerp, Belgium.

Herbert Oberacher (H)

Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, Innsbruck, Austria.

Filip Vanhoenacker (F)

Department of Radiology, Sint-Maarten General Hospital, Mechelen, Belgium; Faculty of Medicine and Health Sciences, Universities of Antwerp and Ghent, Belgium.

Sarah Ceyssens (S)

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.

Sigrid Stroobants (S)

Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Manuel Morrens (M)

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › State-associated changes in longitudinal [
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › State-associated changes in longitudinal [
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › State-associated changes in longitudinal [
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › State-associated changes in longitudinal [
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › State-associated changes in longitudinal [
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › State-associated changes in longitudinal [
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › State-associated changes in longitudinal [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › State-associated changes in longitudinal [
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Cynurénine › State-associated changes in longitudinal [
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › State-associated changes in longitudinal [
questionsmedicales.fr › Cellules › Névroglie › Microglie › State-associated changes in longitudinal [
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › State-associated changes in longitudinal [
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Neuro-immunomodulation › State-associated changes in longitudinal [
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › State-associated changes in longitudinal [
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › State-associated changes in longitudinal [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › State-associated changes in longitudinal [