An exploration of concomitant psychiatric disorders in children with autism spectrum disorder.


Journal

Comprehensive psychiatry
ISSN: 1532-8384
Titre abrégé: Compr Psychiatry
Pays: United States
ID NLM: 0372612

Informations de publication

Date de publication:
01 2019
Historique:
received: 23 04 2018
revised: 04 10 2018
accepted: 25 10 2018
pubmed: 7 12 2018
medline: 7 1 2020
entrez: 4 12 2018
Statut: ppublish

Résumé

We explored patterns of concomitant psychiatric disorders in a large sample of treatment-seeking children and adolescents with autism spectrum disorder (ASD). Participants were 658 children with ASD (age 3-17 years; mean = 7.2 years) in one of six federally-funded multisite randomized clinical trials (RCT) between 1999 and 2014. All children were referred for hyperactivity or irritability. Study designs varied, but all used the Child and Adolescent Symptom Inventory or Early Childhood Inventory to assess Attention Deficit Hyperactivity Disorder (ADHD), Oppositional-Defiant Disorder (ODD), Conduct Disorder (CD), Anxiety Disorders, and Mood Disorders. In addition, several measures in common were used to assess demographic and clinical characteristics. Of the 658 children, 73% were Caucasian and 59% had an IQ >70. The rates of concomitant disorders across studies were: ADHD 81%, ODD 46%, CD 12%, any anxiety disorder 42%, and any mood disorder 8%. Two or more psychiatric disorders were identified in 66% of the sample. Of those who met criteria for ADHD, 50% also met criteria for ODD and 46% for any anxiety disorder. Associations between types of concomitant disorders and a number of demographic and clinical characteristics are presented. In this well-characterized sample of treatment-seeking children with ASD, rates of concomitant psychiatric disorders were high and the presence of two or more co-occurring disorders was common. Findings highlight the importance of improving diagnostic practice in ASD and understanding possible mechanisms of comorbidity.

Identifiants

pubmed: 30504071
pii: S0010-440X(18)30175-5
doi: 10.1016/j.comppsych.2018.10.012
pmc: PMC6295217
mid: NIHMS1511772
pii:
doi:

Types de publication

Journal Article Multicenter Study Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

57-64

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH083739
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000034
Pays : United States
Organisme : NIMH NIH HHS
ID : U10 MH066764
Pays : United States
Organisme : NIMH NIH HHS
ID : U10 MH066768
Pays : United States
Organisme : NIDA NIH HHS
ID : N01MH80011
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH070009
Pays : United States
Organisme : NIMH NIH HHS
ID : U10 MH066766
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000750
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081105
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000052
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081221
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079082
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH070010
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH001805
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083247
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079080
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR006022
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Références

J Child Psychol Psychiatry. 1999 Jan;40(1):57-87
pubmed: 10102726
J Autism Dev Disord. 2000 Jun;30(3):205-23
pubmed: 11055457
Front Hum Neurosci. 2014 Apr 29;8:268
pubmed: 24808851
Arch Gen Psychiatry. 1999 Dec;56(12):1073-86
pubmed: 10591283
Autism. 2011 Sep;15(5):527-43
pubmed: 21454388
Pediatrics. 2006 Oct;118(4):e1203-11
pubmed: 17015508
Autism. 2016 Aug;20(6):663-72
pubmed: 26395234
J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):147-58
pubmed: 11211363
Dev Psychopathol. 2016 Nov;28(4pt1):891-894
pubmed: 27739381
Autism. 2018 Nov;22(8):938-952
pubmed: 28914082
J Autism Dev Disord. 2006 Nov;36(8):1101-14
pubmed: 16897387
J Am Acad Child Adolesc Psychiatry. 2013 Jul;52(7):679-88
pubmed: 23800481
Clin Child Fam Psychol Rev. 2017 Dec;20(4):391-402
pubmed: 28600643
J Autism Dev Disord. 2009 Feb;39(2):278-89
pubmed: 18654843
Lancet. 2005 Jan 1-7;365(9453):82-93
pubmed: 15639683
J Autism Dev Disord. 2013 Apr;43(4):851-9
pubmed: 22895777
JAMA. 2015 Apr 21;313(15):1524-33
pubmed: 25898050
N Engl J Med. 2002 Aug 1;347(5):314-21
pubmed: 12151468
J Am Acad Child Adolesc Psychiatry. 2009 Dec;48(12):1143-54
pubmed: 19858761
J Am Acad Child Adolesc Psychiatry. 2008 Aug;47(8):921-9
pubmed: 18645422
Autism Res. 2012 Jun;5(3):160-79
pubmed: 22495912
Eur Child Adolesc Psychiatry. 2010 Mar;19(3):281-95
pubmed: 20148275
J Autism Dev Disord. 2006 Oct;36(7):849-61
pubmed: 16845581
J Autism Dev Disord. 2013 Oct;43(10):2341-52
pubmed: 23400347
Psychol Sci Public Interest. 2017 Sep;18(2):72-145
pubmed: 29211974
J Autism Dev Disord. 2010 Nov;40(11):1361-70
pubmed: 20309621
Arch Gen Psychiatry. 2005 Nov;62(11):1266-74
pubmed: 16275814
Autism. 2005 Oct;9(4):392-415
pubmed: 16155056
J Autism Dev Disord. 1994 Oct;24(5):659-85
pubmed: 7814313
Pediatrics. 2008 Mar;121(3):e441-8
pubmed: 18310165
J Autism Dev Disord. 2014 May;44(5):1103-16
pubmed: 24165702
J Am Acad Child Adolesc Psychiatry. 2003 Aug;42(8):915-22
pubmed: 12874493
J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905-15
pubmed: 26506581
Am J Psychiatry. 2015 Dec;172(12):1197-206
pubmed: 26315981

Auteurs

Luc Lecavalier (L)

Ohio State University, Nisonger Center, United States of America. Electronic address: luc.Lecavalier@osumc.edu.

Courtney E McCracken (CE)

Emory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: courtney.mccracken@emory.edu.

Michael G Aman (MG)

Ohio State University, Nisonger Center, United States of America. Electronic address: aman.1@osu.edu.

Christopher J McDougle (CJ)

Lurie Center for Autism, Massachusetts General Hospital, United States of America. Electronic address: CMcDougle@partners.org.

James T McCracken (JT)

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California at Los Angeles, United States of America. Electronic address: jmccracken@mednet.ucla.edu.

Elaine Tierney (E)

Johns Hopkins University School of Medicine, United States of America. Electronic address: tierney@kennedykrieger.org.

Tristram Smith (T)

University of Rochester Medical Center, United States of America. Electronic address: Tristram_Smith@URMC.Rochester.edu.

Cynthia Johnson (C)

Cleveland Clinic and Learner College of Medicine, United States of America. Electronic address: johnsoc@ccf.org.

Bryan King (B)

University of California, San Francisco, Department of Psychiatry, Benioff Children's Hospitals, United States of America. Electronic address: bryan.king@ucsf.edu.

Benjamin Handen (B)

University of Pittsburgh School of Medicine, United States of America. Electronic address: handenbl@upmc.edu.

Naomi B Swiezy (NB)

HANDS in Autism Interdisciplinary Training and Resource Center, Indiana University School of Medicine, United States of America. Electronic address: nswiezy@iupui.edu.

L Eugene Arnold (L)

Ohio State University, Nisonger Center, United States of America. Electronic address: l.arnold@osumc.edu.

Karen Bearss (K)

University of Washington, Department of Psychiatry and Behavioral Sciences, United States of America. Electronic address: kbearss@u.washington.edu.

Benedetto Vitiello (B)

Division of Child and Adolescent Neuro-Psychiatry, University of Turin, Italy. Electronic address: bvitiell@unito.it.

Lawrence Scahill (L)

Emory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: lawrence.scahill@emory.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH