PTEN Hamartoma Tumor Syndrome and Immune Dysregulation.
Journal
Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
11
10
2018
revised:
13
11
2018
accepted:
13
11
2018
pubmed:
7
12
2018
medline:
7
12
2018
entrez:
4
12
2018
Statut:
ppublish
Résumé
Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer. This is called PTEN Hamartomous Tumor Syndrome (PHTS). PHTS patients may also have an increased risk of immunological dysregulation, such as autoimmunity and immune deficiencies. The effects of PTEN on the immune system have been studied in murine knockout models demonstrating that loss of PTEN function leads to dysregulation of the immune response. This results in susceptibility to autoimmunity, impaired B cell class switching with subsequent hypogammaglobulinemia. Additionally, a decreased ability of dendritic cells to prime CD8
Identifiants
pubmed: 30504085
pii: S1936-5233(18)30470-4
doi: 10.1016/j.tranon.2018.11.003
pmc: PMC6277246
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
361-367Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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