Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.

Animals Dopamine / physiology Female Ganglia, Invertebrate / physiology HEK293 Cells Homeostasis / physiology Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism Ion Channel Gating / physiology Ion Channels / physiology Male Membrane Potentials / physiology Neurons / metabolism Palinuridae / physiology Protein Processing, Post-Translational Shal Potassium Channels / physiology Sumoylation / physiology
HCN KV4 dopamine metamodulation short-term activity homeostasis stomatogastric

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
23 01 2019
Historique:
received: 30 05 2018
revised: 23 10 2018
accepted: 03 11 2018
pubmed: 7 12 2018
medline: 18 12 2019
entrez: 4 12 2018
Statut: ppublish

Résumé

Neurons operate within defined activity limits, and feedback control mechanisms dynamically tune ionic currents to maintain this optimal range. This study describes a novel, rapid feedback mechanism that uses SUMOylation to continuously adjust ionic current densities according to changes in activity. Small ubiquitin-like modifier (SUMO) is a peptide that can be post-translationally conjugated to ion channels to influence their surface expression and biophysical properties. Neuronal activity can regulate the extent of protein SUMOylation. This study on the single, unambiguously identifiable lateral pyloric neuron (LP), a component of the pyloric network in the stomatogastric nervous system of male and female spiny lobsters (

Identifiants

DOI: 10.1523/JNEUROSCI.1379-18.2018 PMID: 30504282 PMC: PMC6343643
pubmed: 30504282
pii: JNEUROSCI.1379-18.2018
doi: 10.1523/JNEUROSCI.1379-18.2018
pmc: PMC6343643
doi:

Substances chimiques

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 0
Ion Channels 0
Shal Potassium Channels 0
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

596-611

Informations de copyright

Copyright © 2019 the authors 0270-6474/19/390596-16$15.00/0.

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Auteurs

Anna R Parker (AR)

Department of Biology, and.

Lori A Forster (LA)

Neuroscience Institute, Georgia State University, Atlanta, Georgia, 30303.

Deborah J Baro (DJ)

Department of Biology, and dbaro@gsu.edu.
Neuroscience Institute, Georgia State University, Atlanta, Georgia, 30303.
ORCID: 0000-0002-7741-4055

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Structures anatomiques de l'animal › Ganglions des invertébrés › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux contrôlés par les nucléotides cycliques et activés par l'hyperpolarisation › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Ouverture et fermeture des portes des canaux ioniques › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Cellules › Neurones › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Crustacea › Decapoda (crustacea) › Palinuridae › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canaux potassiques Shal › Modulator-Gated, SUMOylation-Mediated,...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Sumoylation › Modulator-Gated, SUMOylation-Mediated,...