Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research.
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
22
08
2018
accepted:
16
11
2018
pubmed:
7
12
2018
medline:
15
2
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
The varying frequencies of pharmacogenetic alleles among populations have important implications for the impact of these alleles in different populations. Current population grouping methods to communicate these patterns are insufficient as they are inconsistent and fail to reflect the global distribution of genetic variability. To facilitate and standardize the reporting of variability in pharmacogenetic allele frequencies, we present seven geographically defined groups: American, Central/South Asian, East Asian, European, Near Eastern, Oceanian, and Sub-Saharan African, and two admixed groups: African American/Afro-Caribbean and Latino. These nine groups are defined by global autosomal genetic structure and based on data from large-scale sequencing initiatives. We recognize that broadly grouping global populations is an oversimplification of human diversity and does not capture complex social and cultural identity. However, these groups meet a key need in pharmacogenetics research by enabling consistent communication of the scale of variability in global allele frequencies and are now used by Pharmacogenomics Knowledgebase (PharmGKB).
Identifiants
pubmed: 30506572
doi: 10.1002/cpt.1322
pmc: PMC6465129
mid: NIHMS999808
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1256-1262Subventions
Organisme : NIGMS NIH HHS
ID : R24 GM061374
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007419
Pays : United States
Informations de copyright
© 2018 The Authors Clinical Pharmacology & Therapeutics © 2018 American Society for Clinical Pharmacology and Therapeutics.
Références
Am J Hum Genet. 2013 Aug 8;93(2):278-88
pubmed: 23910464
Nature. 2011 Jul 13;475(7355):163-5
pubmed: 21753830
Exp Clin Transplant. 2012 Feb;10(1):24-9
pubmed: 22309416
N Engl J Med. 2003 Mar 20;348(12):1170-5
pubmed: 12646676
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Am J Hum Genet. 2014 Aug 7;95(2):183-93
pubmed: 25087612
Nat Genet. 2001 Nov;29(3):265-9
pubmed: 11685208
Clin Pharmacol Ther. 2017 Sep;102(3):397-404
pubmed: 28198005
N Engl J Med. 2009 Feb 19;360(8):753-64
pubmed: 19228618
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
JAMA. 2018 Oct 16;320(15):1531-1532
pubmed: 30264132
JAMA. 2018 Oct 16;320(15):1533-1534
pubmed: 30264136
Hum Genomics. 2015 Jan 07;9:1
pubmed: 25563503
Mt Sinai J Med. 2010 Mar-Apr;77(2):133-9
pubmed: 20309922
BMC Genet. 2013 May 03;14:34
pubmed: 23641907
Virtual Mentor. 2012 Aug 01;14(8):657-63
pubmed: 23351323
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Clin Pharmacol Ther. 2017 Jul;102(1):37-44
pubmed: 27997040
Nat Commun. 2014 Apr 29;5:3513
pubmed: 24781250
Clin Pharmacol Ther. 2013 Sep;94(3):317-23
pubmed: 23698643
Ann Intern Med. 2006 Nov 21;145(10):749-57
pubmed: 17116919
Science. 2008 Feb 22;319(5866):1100-4
pubmed: 18292342
Am J Hum Genet. 2003 Mar;72(3):578-89
pubmed: 12557124
Science. 2002 Apr 12;296(5566):261-2
pubmed: 11954565
Clin Pharmacol Ther. 2014 Nov;96(5):542-8
pubmed: 25099164
Clin Pharmacol Ther. 2011 Mar;89(3):387-91
pubmed: 21270794
Am J Hum Genet. 2017 Apr 6;100(4):635-649
pubmed: 28366442
Am J Hum Genet. 2005 Oct;77(4):519-32
pubmed: 16175499
Pharmacogenomics J. 2018 Jan;18(1):187-195
pubmed: 27779249
Clin Pharmacol Ther. 2015 Aug;98(2):127-34
pubmed: 25974703
PLoS Genet. 2016 May 27;12(5):e1006059
pubmed: 27232753
Clin Pharmacol Ther. 2014 Apr;95(4):376-82
pubmed: 24458010
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):786-91
pubmed: 20080753
Genome Biol. 2002 Jul 1;3(7):comment2007
pubmed: 12184798
Nat Rev Genet. 2004 Aug;5(8):598-609
pubmed: 15266342
Pharmacogenomics. 2008 Nov;9(11):1639-45
pubmed: 19018720
Am J Hum Genet. 2005 May;76(5):894-901
pubmed: 15793703
Science. 2002 Dec 20;298(5602):2381-5
pubmed: 12493913
J Allergy Clin Immunol. 2014 Jan;133(1):16-26
pubmed: 24369795
PLoS Genet. 2005 Dec;1(6):e70
pubmed: 16355252
Nature. 2008 Feb 21;451(7181):998-1003
pubmed: 18288195
BMC Genet. 2017 Nov 28;18(1):99
pubmed: 29179688
Annu Rev Pharmacol Toxicol. 2015;55:89-106
pubmed: 25292429
Ther Drug Monit. 2001 Jun;23(3):232-8
pubmed: 11360031
Nat Commun. 2016 Oct 11;7:12522
pubmed: 27725671
PLoS Med. 2007 Sep;4(9):e271
pubmed: 17896853
Clin Pharmacol Ther. 2017 Aug;102(2):213-218
pubmed: 28002639
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3441-50
pubmed: 26071445
J Racial Ethn Health Disparities. 2016 Sep 8;:
pubmed: 27631381